Gene therapy is emerging as a potential therapeutic approach for cardiovascular pathogenesis. An appropriate therapy may require multiple genes to enhance therapeutic outcome by modulating inflammatory response and angiogenesis in a controlled and time-dependent manner. Thus, the aim of this research was to assess the spatiotemporal efficacy of a dual-gene therapy model based on 3D collagen sca...

Cellular life harbours a fascinating variety of complex processes and we are still at the beginning our understanding these processes. Atomic-scale reconstructions using crystallography or electron microscopy approaches have unveiled great views on cellular components such as proteins higher-order proteinaceous assemblies. However, static techniques do not reveal dynamics studied constructs. Us...

In this paper we formalize sanction-based obligations in the context of Searle’s construction of social reality. In particular, we define obligations using a counts as conditional, Anderson’s reduction to alethic modal logic and Boella and Lesmo’s normative agent. Our analysis presents an alternative criticism to the weakening rule, which has already been criticized in the philosophical literat...

With numerous advancements in novel biochemical techniques, our knowledge of the role of RNAs in the regulation of cellular physiology and pathology has grown significantly over the past several decades. Nevertheless, detailed information regarding RNA processing, trafficking, and localization in living cells has been lacking due to technical limitations in imaging single RNA transcripts in liv...

INTRODUCTION. Angiogenesis, new blood vessel formation, plays a crucial role in tumor growth (1). Vascular Endothelial Growth Factor (VEGF) has been identified as a strong inducer of angiogenesis and several potent small molecule inhibitors of VEGF signaling are currently in clinical development. Although initial studies indicated that VEGF is an endothelial cell (EC) specific factor recent fin...

We investigate unfolding/folding force kinetics in DNA hairpins exhibiting two and three states with newly designed short dsDNA handles (29 bp) using optical tweezers. We show how the higher stiffness of the molecular setup moderately enhances the signal/noise ratio (SNR) in hopping experiments as compared to conventional long-handled constructs (≅700 bp). The shorter construct results in a sig...

We investigate languages for querying and transforming unstructured data by which we mean languages than can be used without knowledge of the structure (schema) of the database. There are two reasons for wanting to do this. First, some data models have emerged in which the schema is either completely absent or only provides weak constraints on the data. Second, it is sometimes convenient, for t...

background: among all cancers, malignancies of gastrointestinal tract are the most common cancer among iranian population. dietary behavior is thought to be the most important risk factor in gastric cancer. fear and perceived severity are two important constructs of the protection motivation theory (pmt). despite the evidence of the impact of these two constructs in modifying dietary habits aga...

MOTIVATION The sequence of artificial genetic constructs is composed of multiple functional fragments, or genetic parts, involved in different molecular steps of gene expression mechanisms. Biologists have deciphered structural rules that the design of genetic constructs needs to follow in order to ensure a successful completion of the gene expression process, but these rules have not been form...