Types of imaging Brain imaging techniques currently used in the UK for the clinical assessment of dementia are grouped into three categories: structural, functional and molecular. Structural imaging includes computed tomography (CT) and magnetic resonance imaging (MRI). The images produced by these methods allow one to see the anatomical ‘structure’ of cerebral tissue. They are used to detect a...

Tumor relapse after initial regression post-chemotherapy is a major challenge in cancer treatment, as it usually leads to local-regional recurrence or inoperable distant metastasis. M2 macrophages diminish the tumor-inhibitory effect of chemotherapy and correlate with distant metastasis and poor prognosis. In this study, we investigated whether molecular imaging of M2 macrophages could serve as...

OBJECTIVE Molecular imaging of nigrostriatal dopamine transporters (DAT) and sympathetic cardiac innervation with single-photon emission computed tomography (SPECT) are useful tools for differentiating idiopathic Parkinson disease (PD) from other degenerative parkinsonian syndromes (non-PD). Nevertheless, these modalities are often insufficient for achieving a definite diagnosis. The aims of th...

UNLABELLED We present a new rodent SPECT system (U-SPECT-II) that enables molecular imaging of murine organs down to resolutions of less than half a millimeter and high-resolution total-body imaging. METHODS The U-SPECT-II is based on a triangular stationary detector set-up, an XYZ stage that moves the animal during scanning, and interchangeable cylindric collimators (each containing 75 pinho...

OBJECTIVE Comparison of 201Tl chloride SPECT (TI-SPECT) with 99mTc-MIBI SPECT (MIBI-SPECT) in the depiction of malignant head and neck tumors was prospectively studied. METHODS Forty-one patients with various tumors of the head and neck were included in this prospective study. Histologically, 36 patients had squamous cell carcinomas, 3 undifferentiated carcinomas, 1 transitional cell carcinom...

objective: iqspect is an advanced high-speed spect modality for performing myocardial perfusion imaging (mpi), which uses a multi-focus fan beam collimator with resolution recovery reconstruction. the aim of this study was to compare iqspect compared with conventional spect interms of performance based on standard clinical protocols. in addition, we examined the concordance between conventional...

The fields of molecular biology, immunology and genetics have generated many important developments that advance the understanding of the induction and progression of oncological, cardiological and neurological diseases as well as the identification of disease-associated molecules and drugs that specifically target diseased cells during therapy. These insights have triggered the development of ...

introduction: although pet scanning using f-18[fdg] is considered the superior radiotracer for tumnor imaging, gallium-67 is still in use for some malignancies such as lymphoma and hepatoma. one of the strategies to improve the diagnostic accuracy of gallium is to perform spect which is reported to be more sensitive compared to planar imaging. in this study we compared the sensitivity of spect ...

Molecular Imaging has evolved over the past decade as an integrated medical discipline, which incorporates fundamental knowledge from cell biology, molecular biology and diagnostic imaging. The discipline was initially driven by in-situ visualization of target molecules and biological processes [3–6]. More recently, the term ‘Molecular Imaging’ has been used for the noninvasive imaging of molec...

UNLABELLED An accurate and noninvasive tracer able to detect molecular events underlying the development of rheumatoid arthritis (RA) would be useful for RA diagnosis and drug efficacy assessment. A complement receptor of the Ig superfamily (CRIg) is expressed on synovial macrophages of RA patients, making it an interesting target for molecular imaging of RA. We aim to develop a radiotracer for...