Aspects of the molecular-level basis for the function of ethylene glycol dimethacrylate and trimethylolproprane trimethacrylate crosslinked methacrylic acid copolymers molecularly imprinted with (S)-propranolol have been studied using a series of all-component and all-atom molecular dynamics studies of the corresponding prepolymerization systems. The crosslinking agents were observed to contrib...

A molecularly imprinted silica gel sorbent for selective removal of 2-Hydroxybenzoic acid (2-HA) was prepared by a surface imprinting technique with a sol-gel process. The 2-HA molecularly imprinted silica gel (2-HA-MISG) sorbent was evaluated by various parameters, including the influence of pH, static, kinetic adsorption and selectivity experiments. The optimum adsorption capacity to the 2-HA...

The development of genomics-based technologies is demonstrating that many common diseases are heterogeneous collections of molecularly distinct entities. Molecularly targeted therapeutics is often e ective only for some subsets patients with a conventionally de ned disease. We consider the problem of design of phase III randomized clinical trials for the evaluation of a molecularly targeted tre...

BACKGROUND The tolerability of molecularly targeted agents in older patients has not been specifically examined. Adverse event data from clinical trials in the Princess Margaret Hospital Phase II Consortium database were analyzed to address this question. METHODS The Consortium database collects trial information on all patients treated with either a molecularly targeted agent alone or in com...

By combining the specific molecular recognition capability of MIPs and the asymmetric structure of Janus particles, the Janus MIP particles which were synthesized via a wax-water Pickering emulsion showed attractive capabilities as self-propelled transporters for controlled drug delivery.

BACKGROUND In evaluation of the clinical benefit of a new targeted agent in a phase 3 trial enrolling molecularly selected patients with advanced non-small cell lung cancer (NSCLC), overall survival (OS) as an endpoint seems to be of limited use because of a high level of treatment crossover for ethical reasons. A more efficient and useful indicator for assessing efficacy is needed. METHODS A...

cognitive linguistics gives the most inclusive, consistent description of how language is organized, used and learned to date. cognitive linguistics contains a great number of concepts that are useful to second language learners.  if-clauses in english, on the other hand, remain intriguing for foreign language learners to struggle with, due to their intrinsic intricacies. efl grammar books are ...

In an attempt to generate a suitable animal model to study the infectivity and possible pathogenicity of human immunodeficiency viruses, we intravenously inoculated juvenile rhesus macaques and African green monkeys with a molecularly cloned virus, human immunodeficiency virus type 2 HIV-2sbl/isy, as well as with the uncloned HIV-2nih-z virus. Infection was monitored by virus recovery from the ...