insulin dysfunction in conjugation with gross abnormalities in glucose homeostasis and lipid metabolism, which has affecting several millions of population all over the world. The individual with diabetes has a 25-fold increase in the risk of blindness, a 20-fold increase in the risk of renal failure, a 20-fold increase in the risk of amputation as a result of gangrene and a 2 to 6 fold increas...

Diabetes mellitus (DM) is a serious metabolic disorder with micro and macro-vascular complications that result in a significant morbidity and mortality. The present study investigated the effects of Momordica charantia (M. charantia) on histological changes of the aorta and pulmonary trunk in streptozotocin-induced diabetic Wistar rats. Forty healthy adult Wistar rats of both sexes were randoml...

It has been reported that the water extract of the whole unripe fruit of Momordica charantia can significantly reduce blood glucose levels. However the safety of its use during pregnancy has not been fully investigated. The aim of this investigation is to determine the safety of this extract during pregnancy. The water extract of the unripe fruit was given to pregnant Sprague Dawley rats on day...

Bitter gourd (Momordica charantia), a commonly consumed vegetable is used as an adjunct in the management of diabetes mellitus. A study was carried out to examine the effect of edible portion of bitter gourd at 10% level in the diet in streptozotocin induced diabetic rats. To evaluate the glycaemic control of bitter gourd during diabetes, diet intake, gain in body weight, water intake, urine su...

Objective: The present study was conducted to determine the hypoglycemic and antioxidant potential of polyherbal formulation in alloxan induced diabetic rats. Study Design: In five different groups an aqueous suspension of herbal mixture containing equal amounts of– Azadirachta indica, Gymnema sylvestre, Momordica charantia, Syzigium cumini, Trigonella foenum was administered orally once a day ...

Diabetes mellitus (DM) is the most common of the endocrine disorders and represents a global health problem. DM is characterized by chronic hyperglycaemia due to relative or absolute lack of insulin or the actions of insulin. Insulin is the main treatment for patients with type 1 DM and it is also important in type 2 DM when blood glucose levels cannot be controlled by diet, weight loss, exerci...

The immunological effect of an extract from Momordica cochinchinensis seed (ECMS) on immune responses against infectious bursal disease (IBD) in chickens was evaluated. Fifty-two birds were equally divided into 4 groups and immunized with inactivated IBD vaccine alone (controls) or IBD vaccine emulsified with ECMS (20, 40, and 80 microg). Serum IgG antibody levels against IBD and BW were measur...

The landrace strains of Momordica charantia are widely cultivated vegetables throughout the tropics and subtropics, but not in Taiwan, a continental island in Southeast Asia, until a few hundred years ago. In contrast, the related wild populations with smaller fruit sizes are native to Taiwan. Because of the introduction of cultivars for agricultural purposes, these two accessions currently exh...

The effect of karela (Momordica charantia), a fruit indigenous to South America and Asia, on glucose and insulin concentrations was studied in nine non-insulin-dependent diabetics and six non-diabetic laboratory rats. A water-soluble extract of the fruits significantly reduced blood glucose concentrations during a 50 g oral glucose tolerance test in the diabetics and after force-feeding in the ...