to develop a new more accurate spectrophotometric method for detecting monoamine oxidase inhibitors from plant extracts, a series of amine substrates were selected and their ability to be oxidized by monoamine oxidase was evaluated by the hplc method and a new substrate was used to develop a peroxidase-linked spectrophotometric assay. 4-(trifluoromethyl) benzylamine (11) was proved to be an exc...

Various pharmacological approaches to potentiate the therapeutic actions of levodopa and reduce side-effects are reviewed. Of currently available drugs, anticholinergic agents and amantadine have been studied extensively. Inhibition of extracerebral decarboxylase appears to be the most promising new area of investigation, though experience is at present limited. Other methods discussed include ...

An efficient one-pot synthesis of the cis-pyridylimine palladium (II) complexes is reported. The compo- sition and structure were proved by NMR, IR, X-ray, elemental analysis. monoamine oxidase inhibition activity synthesized complexes, including six previously unknown, inves- tigated on native mouse brains. Some compounds: cis-dichlorido-2,6-dimethyl-N- ((pyridin-2-yl)methylene)anilinepalladiu...