It is well established that tobacco smokers have reduced levels of monoamine oxidase activities both in the brain and peripheral organs. Furthermore, extensive evidence suggests that smokers are less prone to develop Parkinson's disease. These facts, plus the observation that inhibition of monoamine oxidase B protects against the parkinsonian inducing effects of the nigrostriatal neurotoxin 1-m...

When rat liver mitochondria are treated with the phospholipase A2 isolated from Naja naja venom in amounts sufficient to cause about 70% loss of mitochondrial phospholipids, both of the monoamine oxidase isozymes monoamine oxidase A and monoamine oxidase B are reduced in activity. With both monoamine oxidases, phospholipase treatment affects the enzyme’s affinity for the amine substrates rather...

In this study we synthesized and evaluated a new series of amino and nitro 3-arylcoumarins as hMAO-A and hMAO-B inhibitors. Compounds 2, 3, 5 and 6 presented a better activity and selectivity profile against the hMAO-B isoform (IC50 values between 2 and 6nM) than selegiline. In general, the amino derivatives (4-6) proved to be more selective against MAO-B than the nitro derivatives (1-3). Addit...

SSRIs are chemically distinct from traditional antidepressants such as tricyclic, tetracyclic, and monoamine oxidase inhibitors, but they share the same mechanism of action in that selectively potently inhibit serotonin neuronal reuptake while having no or very little effect on norepinephrine, acetylcholine, histamine reuptake. As a result, when compared to other tricyclic tetracyclic antidepre...

Extensive use of monoamine oxidase inhibitors and imipramine in psychiatric practice has revealed serious toxic reactions. It has been observed that combination of monoamine oxidase inhibitor and imipramine produces a symptom complex characterized by hyperexcitement, motor restlessness and hyperpyrexia (1-6). Furthermore, hypertensive crisis, subarachnoid haemorrhage and pulmonary oedema has be...