Acrylic base resins are widely used in orthopedics and dental surgery. It is generally accepted that due to the incomplete conversion of methyl methacrylate (MMA) monomer to the polymer form during polymerization of the resin, some MMA monomers remain in the hardened material. MMA monomer has been reported to cause abnormalities or lesions in several organs of animals. Study of the literatures ...

The Listeria monocytogenes ActA protein induces actin-based motility by enhancing the actin nucleating activity of the host Arp2/3 complex. Using systematic truncation analysis, we identified a 136-residue NH(2)-terminal fragment that was fully active in stimulating nucleation in vitro. Further deletion analysis demonstrated that this fragment contains three regions, which are important for nuc...

poly(vinyl acetate) is synthesized via solution polymerization, and then it is converted to poly(vinyl alcohol) by alkaline alcoholysis. the aim of the work study was to investigate statistically the  influence of reaction variables in vinyl acetate polymerization, the conversion of this monomer to polymer, degree of branching of acetyl group in poly(vinyl acetate), as well as the molecular wei...

Although the growth factor receptor binder 2 (Grb2)-Grb2-associated binder (Gab)1 macromolecular complex mediates a multitude of cellular signaling cascades, the molecular basis of its assembly has hitherto remained largely elusive. Herein, using an array of biophysical techniques, we show that, whereas Grb2 exists in a monomer-dimer equilibrium, the proline-rich (PR) domain of Gab1 is a monome...

The universal sesquiterpene precursor, farnesyl diphosphate (FPP), is cyclized in an Mg(2+)-dependent reaction catalyzed by the tetrameric aristolochene synthase from Aspergillus terreus to form the bicyclic hydrocarbon aristolochene and a pyrophosphate anion (PP(i)) coproduct. The 2.1-A resolution crystal structure determined from crystals soaked with FPP reveals the binding of intact FPP to m...

grafting polymerization was a valuable method for the modification of the chemical and physical properties of polymer surfaces. in this paper, the grafting of cationic vinyl monomer with quaternary ammonium groups, methacryloxyethyltrimethyl ammonium chloride (dmc), onto the isotactic polypropylene (ipp) granule was performed by suspension solid-state grafting process. the technique offers new ...

The need to engineer novel therapeutics and functional materials is driving the in-silico design of molecular complexes. This paper proposes a method to compute symmetric homo-oligomeric protein complexes when the structure of the replicated protein monomer is known and rigid. The relationship between the structure of a protein and its biological function brings the in-silico determination of p...

AcrAB-TolC is the major efflux protein complex in Escherichia coli extruding a vast variety of antimicrobial agents from the cell. The inner membrane component AcrB is a homotrimer, and it has been postulated that the monomers cycle consecutively through three conformational stages designated loose (L), tight (T), and open (O) in a concerted fashion. Binding of drugs has been shown at a peripla...

An amphiphilic dipeptide (1) bearing pyrene and phenylboronic acid was demonstrated as a unique example of a ratiometric sensing system for sugars by reversibly converting the peptide aggregates into the monomer form of the complex with sugars in aqueous solutions.