Release of free fatty acid (FFA) from adipose tissue is implicated in insulin resistance and endothelial dysfunction in patients with visceral fat obesity. We demonstrated previously that increased FFA levels cause endothelial dysfunction that is prevented by inhibition of the renin-angiotensin system (RAS) in humans. However, the mechanisms for FFA-mediated activation of RAS and the resultant ...

2-(3-Methyl-cinnamyl-hydrozono)-propionate stimulated glucose oxidation in human mononuclear leukocytes and the stimulation was similar to that by concanavalin A. Both substances must affect glucose metabolism at two sites, the first site being before the pyruvate dehydrogenase step because of the increase of lactate plus pyruvate concentration. The second site is related to pyruvate oxidation....

By Nic.uioi s L. PETRAKIS, M iu DAVIS A D SALVATORE P. Lucia O NE OF the important controversies ( f morphologic hematology concerns the concept that some of the nc’igranular mononuclear Ieukocytes of the circulating blood have the potential for further differentiation toward connective tissue and he natopoietic cells. A relationship between leukocytes of the blood and connective tissue was sug...

In the rabbit model of electrically induced intimal thickening, the adherence processes of different leukocyte subsets as well as the functional significance of leukocyte invasion in the initial migration of smooth muscle cells (SMCs) into the intima were studied by using monoclonal antibody (MAb) 60.3 (directed to the leukocyte adherence glycoprotein CD18), a known potent inhibitor of leukocyt...

The capacity of rabbit mononuclear cells to release an endogenous pyrogen (EP) in vitro has been studied. After incubation with tuberculin, preparations of predominantly monocytic cells, derived from the respiratory passages of the lungs of rabbits sensitized with BCG, were activated to release EP. Pyrogen production occurred more slowly with lung monocytes than with blood leukocytes of similar...

By Nic.uioi s L. PETRAKIS, M iu DAVIS A D SALVATORE P. Lucia O NE OF the important controversies ( f morphologic hematology concerns the concept that some of the nc’igranular mononuclear Ieukocytes of the circulating blood have the potential for further differentiation toward connective tissue and he natopoietic cells. A relationship between leukocytes of the blood and connective tissue was sug...

By Nic.uioi s L. PETRAKIS, M iu DAVIS A D SALVATORE P. Lucia O NE OF the important controversies ( f morphologic hematology concerns the concept that some of the nc’igranular mononuclear Ieukocytes of the circulating blood have the potential for further differentiation toward connective tissue and he natopoietic cells. A relationship between leukocytes of the blood and connective tissue was sug...

Bronchiolitis obliterans syndrome (BOS) is the major limitation to survival after lung transplantation. Acute rejection, its main risk factor, is characterized by perivascular/bronchiolar leukocyte infiltration. BOS is characterized by persistent peribronchiolar leukocyte recruitment leading to airway fibrosis and obliteration. The specific mechanism(s) by which these leukocytes are recruited a...

Platelets induce generation of procoagulant tissue factor activity (TFa) by mononuclear leukocytes, and also enhance the TFa induced by endotoxin. Our present investigation demonstrated that arachidonic acid, which by itself had no effect on mononuclear TFa, greatly enhanced platelet-induced TFa. The effect was concentration dependent for both platelets and arachidonate (1-20 microM); other fat...

Recently it has been hypothesized that leukocyte rheology could be a relevant variable of the microcirculation during cerebral ischemia. However, relatively few studies have been carried out on the rheologic behavior of leukocytes in vascular diseases. This study aimed at quantifying the filterability through Nuclepore filters (mean pore diameter 5 microns) of both leukocyte subpopulations and ...