Software Conceptual Integrity has been considered a cardinal concern for design and development of software systems. But, except for verbal descriptions of desiderata, there were no formal tools to guarantee that conceptual integrity is attained. This paper proposes an axiomatic algebraic approach, based upon the assumption that the software system in each level of the system hierarchy is repre...

INTRODUCTION The precise time of using percutaneous coronary intervention (PCI) after fibrinolytic therapy for maximum efficiency and minimum side effects is still undetermined. Therefore, the present study was designed to compare the outcome of myocardial infarction (MI) patients who underwent surgical intervention (angiography and PCI) within 48 hours of thrombolytic therapy or after that. ...

The duration of glucocorticoid-induced inhibition that occurs in the hypothalamic-pituitary-adrenal (HPA) axis after discontinuation of treatment is controversial. The main objective of this prospective study was to evaluate the inhibition of the HPA axis by dexamethasone in children and adolescents with acute lymphoid leukemia. Thirty-five patients (median age of 6.9 yr) were evaluated. A stim...

Progressive skeletal disease accounts for some of the most debilitating complications of type 1 Gaucher disease. In this 48-month, prospective, non-randomized, open-label study of the effect of enzyme replacement therapy on bone response, 33 imiglucerase-naïve patients (median age 43 years with one or more skeletal manifestations such as osteopenia, history of bone crisis, or other documented b...

Recall the global U(1) symmetry: Ψ→ e−ieΨ i.e. δΨ = −ieΨ. Let’s run the Noether argument: consider a slightly deformed, infinitesimal version of the symmetry transformation: Ψ→ Ψ + ρδΨ, where is just a small number to keep track of order, and ρ is some general function of x. The fact that we have a U(1) symmetry tells us the action must change under the deformed transformation by δS = ∫ dx J N∂...

BACKGROUND The clinical value of quantitative hepatitis B surface antigen (qHBsAg) titre in patients taking nucleotide/nucleoside analogues (NAs) is still controversial. This study aims to investigate the dynamic changes of qHBsAg titres and their significance for predicting virological response (VR) and serological response (SR) to long-term entecavir (ETV) treatment. METHODS A total of 48 E...

This paper discusses Brooks’ The Mythical Man-Month, a landmark work in the software project management field, and compares the software project management advice given there with practices employed some 25 years later. To find out the state of today’s practice 20 experienced software developers were interviewed regarding their impressions of factors leading to success or failure of software de...