This study investigated the requirements for restoring motor function after corticospinal (CS) system damage during early postnatal development. Activity-dependent competition between the CS tracts (CSTs) of the two hemispheres is imperative for normal development. Blocking primary motor cortex (M1) activity unilaterally during a critical period [postnatal week 5 (PW5) to PW7] produces permanen...

BACKGROUND Obsessive-compulsive disorder (OCD) has been associated with impairments in stop-signal inhibition, a measure of motor response suppression. The study used a novel paradigm to examine both thought suppression and response inhibition in OCD, where the modulatory effects of stimuli relevant to OCD could also be assessed. Additionally, the study compared inhibitory impairments in OCD pa...

It well recognized that children with cerebral palsy (CP) have somatosensory processing deficits that limit their proprioception, stereognosis, and tactile discrimination. Since CP involves damage to both the sensory and motor systems, it is unclear whether the noted sensory deficits contribute to the motor impairments seen in these children, or if they are more independent symptoms that share ...

Vitamin D is a neuroactive seco-steroid and its importance to the nervous system is receiving increasing recognition. Since numerous data link vitamin D dysfunctions to various neurological and behavioural disorders, we studied whether genetic ablation of vitamin D receptors (VDR) may be associated with motor impairments in mice subjected to several behavioural tests. The data obtained in the v...

objectives: cerebral palsy (cp) describes a group of disorders in the development of movement and posture in the developing brain. the main aim of this study was to determine the distribution of motor impairment and associated disorders in a population of children with cp. methods: this study was carried out in 2011 during three months, on 200 cp children. multiple sources of ascertainment were...

Impairments of sensorimotor function are evident in individuals with lateral elbow tendinopathy (LET), although understanding the mechanisms for this is lacking. To determine if motor imagery, tactile acuity and wrist joint position sense (JPS) impaired participants unilateral LET compared to controls, whether deficits localised affected side, relate severity pain. Cross-sectional study control...

Antenatal brain hypoxia-ischemia, which occurs in cerebral palsy, is considered a significant cause of motor impairments in children. The mechanisms by which antenatal hypoxia-ischemia causes brain injury and motor deficits still need to be elucidated. Tetrahydrobiopterin is an important enzyme cofactor that is necessary to produce neurotransmitters and to maintain the redox status of the brain...

AIM The aim of the study was to investigate whether impairments associated with cerebral palsy were stable between childhood and adolescence. METHOD The Study of Participation of Children with Cerebral Palsy Living in Europe (SPARCLE) longitudinal study was conducted in nine European regions. In total, 818 children aged 8 to 12 years were randomly selected from population-based registers; 594...

Touchscreen devices have rapidly become one of the most pervasive video game platforms in the world and, in turn, an integral part of popular culture; however, little work exists on comprehensively examining their accessibility. In this poster paper, we present initial findings from a survey and qualitative analysis of popular iPad touchscreen games with a specific focus on exploring factors re...