Diethylstilbestrol (DES) was widely used in the past, as the morning after contraception, but its application became extremely limited due to several complications including delayed clear cell adenocarcinoma in female infants. However, the use of DES increased during the past decade for hormone replacement therapy. The aim of this study was to investigate possible teratogenicity of this...

Kate McDole is a Group Leader at the MRC Laboratory of Molecular Biology (LMB) in Cambridge, UK. Using mouse embryo as model, Kate's research group studies how mechanical forces can shape complex three-dimensional structures out simple populations cells. We met with to find more about her career, challenges setting up lab during pandemic, and thoughts on mentorship transitioning leader position.

nowadays gamete and embryo freezing is an appropriate approach for preserving of genetic traits in laboratory animals, rare and endangered species. frozen cells are suitable replace for actively breeding animals colony. the aim of this study was to perserve laboratory mouse embryo, using vitrification method and comparing effect of two cryoprotectants, glycerol-sucrose(gs) and ethylene glycol-f...

introduction: the purpose of this study was to investigate the effect of rpmi and t6 medium on two cell mouse embryo co-culture with vero cells. materials and methods: two cell mouse embryos (nmri strain) were flushed from the excised uteri of superovulated mice. morphologically normal embryos were divided into four groups: the first control group was cultured on t6 media. the first experimenta...

Leptin acts as a modulator of diverse reproductive functions, and recent studies have implicated involvement of leptin in the early embryo development in mammal. The aim of this study was to investigate the expression of leptin and its receptor (OB-R) in mouse oocyte and preimplantation embryo, and to examine whether leptin influenced the early embryo development. Leptin mRNA was detected in bl...

Mouse embryonic stem cells are continuous cell lines derived directly from the fetal founder tissue of the preimplantation embryo. They can be expanded in culture while retaining the functional attributes of pluripotent early embryo cells. In particular, they can participate fully in fetal development when reintroduced into the embryo. The capacity for multilineage differentiation is reproduced...

diethylstilbestrol (des) was widely used in the past, as the morning after contraception, but its application became extremely limited due to several complications including delayed clear cell adenocarcinoma in female infants. however, the use of des increased during the past decade for hormone replacement therapy. the aim of this study was to investigate possible teratogenicity of this synthet...

A cytoplasmic component(s), previously shown to rescue the 'blocked' 2-cell mouse embryo in vitro, has been demonstrated to peak in activity during the transition between G2 and M phase and decline thereafter. The possible significance of this component(s) in the regulation of cleavage of the cultured mouse embryo is discussed.