p53 tumor suppressor is a transcription factor that functions, in part, through many of its downstream target genes. We have identified a p53-inducible gene by performing mRNA differential display on IW32 murine erythroleukemia cells containing a temperature-sensitive p53 mutant allele, tsp53(Val-135). Sequence analysis of the full-length cDNA revealed its identity as the mouse homologue of the...

An inkjet printed, biocompatible, heterostructure photodetector is described that was constructed using inks of photo-active molybdenum disulfide (MoS2) and electrically conducting graphene which facilitated charge collection of the photocarriers. The importance of such devices stems from their potential utility in age-related-macular degeneration, which is a condition where the photosensitive ...

Mouse embryonic stem cells (mESCs) were first derived and cultured almost 30 years ago and ever since have been valuable tools for creating knockout mice and for studying early mammalian development. More recently (1998), human embryonic stem cells (hESCs) have been derived from blastocysts, and numerous methods have evolved to culture hESCs in vitro in both complex and defined media. hESCs are...

Autophagy contributes to sebaceous gland function and the control of sebum composition. Based on literature data, autophagy markers were strongly expressed in maturing cells healthy skin, whereas downregulated acne-involved glands. Interestingly, tissue transglutaminase (TG2) which is known regulate mouse embryonic fibroblast has a potential role also integrity epidermis exerts an abundant expr...

Hypersecretion of gastric acid damages the stomach lining, causing formation peptic ulcers. Mucilage from medicinal plants offers a relaxing and soothing effect to endodermal lining gut has antacid properties, which can protect mucosal acidity. This is first report aimed evaluate physicochemical characteristics, acid-neutralizing, cytotoxicity properties traditionally used aqueous mucilage Aspa...

L-methioninase degrades methionine, which is essential in methionine-dependent cancer cells, resulting specific cell death. Normal cells can synthesize their own methionine amino acids even the absence of exogenous methionine. This selective targeting makes a promising therapeutic candidate for cancer. In this study, was partially purified from Brevibacterium linens BL2. The activity enzyme fou...

The aim of this study was to isolate mouse embryonic stem cells from late blastocyst stage embryos and to use them as a model system for the study of hematopoietic induction outside the embryo by coculturing of embryonic stem cells with bone marrow stromal cells. Blastocyst stage embryos from pregnant NMRI mice were obtained and cultured for 1-2 days in DMEM medium. The inner cell masses formed...