A wide range of etiologies may present as multiple ring-enhancing lesions in brain, including infectious, neoplastic, vascular or inflammatory etiology. MR spectroscopy is a potential tool which images at the molecular level analyzing the chemical composition of tissue metabolites like NAA, creatine, choline and lipid etc. Another advantage of MR spectroscopy is that, it can be added as a seque...

Proton nuclear magnetic resonance spectroscopy ((1)H-NMRS) is a noninvasive in vivo technique that utilizes conventional MR imaging hardware to obtain biochemical information from a discrete volume of tissue after suppression of the water signal. MR spectroscopy coupled with conventional MR imaging allows correlation of structural changes with biochemical processes in tissues by measuring speci...

BACKGROUND AND PURPOSE MR imaging has made it easier to distinguish among the different types of intracranial mass lesions. Nevertheless, it is sometimes impossible to base a diagnosis solely on clinical and neuroradiologic findings, and, in these cases, biopsy must be performed. The purpose of this study was to evaluate the hypothesis that proton MR spectroscopy is able to improve preoperative...

We herein describe the case of a patient with chronic renal failure complicated by star fruit poisoning. T2-weighted and diffusion-weighted MR imaging showed hyperintense lesions at the thalami and right temporo-occipital cortex. Single voxel proton MR spectroscopy revealed elevation of lactate and (31)phosphorous MR spectroscopy revealed elevation of inorganic phosphate and decrease of phospho...

A 61-year old female presented with a headache. CT and MR imaging showed a left frontal dural-based mass mimicking meningioma. H-MR spectroscopy showed elevated lipid peaks and decreased N-aspartate, choline and creatine peaks. No abnormal alanine peak was detected. The histological diagnosis was intracranial Rosai-Dorfman disease. Our case suggests that H-MR spectroscopy provides useful inform...

BACKGROUND The purpose of this study was to evaluate the suitability of MR Spectroscopy in screening for prostate cancer in comparison to T2-weighted MR imaging. MATERIALS AND METHODS Forty-six patients with biopsy confirmed prostate cancer underwent combined endorectal-body-phased-array MRI at 1.5T (Tesla). Twelve patients were additionally examined with 3D-spectroscopy sequence. The results...

BACKGROUND AND PURPOSE Severe and progressive neurologic disease remains a problem for patients with hyperphenylalaninemia due to a deficiency of tetrahydrobiopterin (BH4), even with early diagnosis and despite treatment with BH4 and neurotransmitter precursors. Few reports have included the associated imaging characteristics. Our purpose was to describe the imaging features of BH4-deficient pa...

OBJECTIVE To describe the spectrum of Magnetic Resonance spectroscopy in focal brain lesions and determine its diagnostic accuracy using histopathology as gold standard in differentiating neoplastic and non-neoplastic focal brain lesions. METHODS The study was conducted in Department of Radiology, Aga Khan University Hospital, Karachi from Dec 2006 till Jan 2009. Fifty three patients found to...