A. Henning, M. Schär, R. F. Schulte, K. P. Pruessmann, P. Boesiger Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Kanton Zurich, Switzerland, John Hopkins University, Baltimore, MD, United States Introduction In spite of significantly improved saturation pulses [1,2] sufficient outer volume (OVS) and especially fat suppression in MRSI could only be achieved in combinat...

Introduction: Estimates of brain metabolites using whole-slice or large-volume magnetic resonance spectroscopic imaging (MRSI) are severely hampered by strong lipid signals even though the interfering signal arises from regions outside of the brain, namely subcutaneous tissue, scalp, and bone marrow. Many lipid suppression methods have been proposed, including outer-volume suppression (OVS) [1-...

PURPOSE To improve signal-to-noise ratio (SNR) for high-resolution spectroscopic imaging using a subspace-based technique known as SPectroscopic Imaging by exploiting spatiospectral CorrElation (SPICE). METHODS The proposed method is based on a union-of-subspaces model of MRSI signals, which exploits the partial separability properties of water, lipid, baseline and metabolite signals. Enabled...

OBJECTIVE To determine cerebral regional concentrations of N-acetyl aspartate (NAA), total choline (Cho), and total creatine (Cr) in Rett syndrome (RS) using 1H magnetic resonance spectroscopic imaging (MRSI). BACKGROUND The biochemical defect underlying RS is unknown. Because in vivo MRSI can detect important cerebral metabolites, MRSI has a potential to reveal impairment of regional cerebra...

Short echo time proton MR Spectroscopic Imaging (MRSI) suffers from low signal-to-noise ratio (SNR), limiting accuracy to estimate metabolite intensities. A method to coherently sum spectra in a region of interest of the human brain by appropriate peak alignment was developed to yield a mean spectrum with increased SNR. Furthermore, principal component (PC) spectra were calculated to estimate t...

Introduction MRI techniques have recently demonstrated the ability to provide valuable anatomic imaging in the newborn brain, but additional metabolic markers would be important to provide improved assessments of neonatal brain injury. 3D point-resolved spectroscopic imaging (PRESS-MRSI) can provide accurate measurements of metabolite levels throughout the brain, but it is more complex than com...

Introduction: Presence of lipids in brain parenchyma may indicate the active deor re-myelination in multiple sclerosis (MS). Magnetic resonance spectroscopic imaging (MRSI) can provide tissue biochemical information in vivo. Manual examination of each voxel for the presence of lipid peak in MRSI data is tedious due to the number of voxels. This problem becomes more acute in multicenter clinical...

The goal of this study was to evaluate a new method of combining multi-channel (1)H MRSI data by direct use of a matching imaging scan as a reference, rather than computing sensitivity maps. Seven healthy volunteers were measured on a 7-T MR scanner using a head coil with a 32-channel array coil for receive-only and a volume coil for receive/transmit. The accuracy of prediction of the phase of ...

OBJECTIVES To assess the accuracy of magnetic resonance (MR) spectroscopic imaging (1H-MRSI) and dynamic contrast-enhanced MR (DCEMR) in the depiction of local prostate cancer recurrence in patients with biochemical progression after radical prostatectomy (RP). MATERIALS AND METHODS 1H-MRSI and DCEMR were performed in 70 patients at high risk of local recurrence after RP. The population was d...

OBJECTIVE Explosive blast mild traumatic brain injury (mTBI) is associated with a variety of symptoms including memory impairment and posttraumatic stress disorder (PTSD). Explosive shock waves can cause hippocampal injury in a large animal model. We recently reported a method for detecting brain injury in soldiers with explosive blast mTBI using magnetic resonance spectroscopic imaging (MRSI)....