نتایج جستجو برای: mtd
تعداد نتایج: 1531 فیلتر نتایج به سال:
DNA damage stabilizes the p53 tumor suppressor protein that determines the cell fate by either cell cycle arrest or cell death induction. Noxa, the BH3-only Bcl-2 family protein, was shown to be a key player in p53-induced cell death through the mitochondrial dysfunction; however, the molecular mechanism by which Noxa induces the mitochondrial dysfunction to cause cell death in response to geno...
Methadone is a synthetic analgesic widely used in methadone maintenance programmes. Methadone (MTD) is generally administered orally as a racemate, however the therapeutic effect is almost exclusively mediated by the (R)-enantiomer since its affinity for the μ-opioid receptor and its analgesic effect is up to 8 and 50 times, respectively, greater than for the (S)-enantiomer. Because of importan...
PURPOSE Most primary human ovarian tumors and peritoneal implants, as well as tumor vascular endothelial cells, express the CD44 family of cell surface proteoglycans, the natural ligand for which is hyaluronic acid. Metronomic dosing, the frequent administration of chemotherapeutics at substantially lower than maximum tolerated doses (MTD), has been shown to result in reduced normal tissue toxi...
Bacteriophage BPP-1, which infects Bordetella species, can switch its specificity by mutations to the ligand-binding surface of its major tropism-determinant protein, Mtd. This targeted mutagenesis results from the activity of a phage-encoded diversity-generating retroelement. Purified Mtd binds its receptor with low affinity, yet BPP-1 binding and infection of Bordettella cells are efficient b...
Objectives: To compare five molecular targeted drugs (MTD) with interferon-α (IFN-α) and evaluate their clinical efficacy and adverse events as first line therapy for metastatic renal cell carcinoma (mRCC). Methods: We conducted a systemic review and network meta-analysis of all relevant randomized controlled trials (RCTs) assessing MTD and IFN-αthrough a comprehensive search of databases inclu...
Phage display offers a powerful approach to engineer protein affinity. A naturally occurring analog to phage display, the Bordetella bronchiseptica bacteriophage (BP) employs a highly variable protein termed the major tropism determinant (Mtd) to recognize its dynamic host. Propagation of BP provides a self-made phage library (SMPL) with vast numbers of phage particles, each displaying a single...
Our previous observation that host plant extracts induce production and secretion of mannitol in the tobacco pathogen Alternaria alternata suggested that, like their animal counterparts, plant pathogenic fungi might produce the reactive oxygen quencher mannitol as a means of suppressing reactive oxygen-mediated plant defenses. The concurrent discovery that pathogen attack induced mannitol dehyd...
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