The objective of this study was to develop intranasal nanoemulsion and gel formulations for rizatriptan benzoate for prolonged action. Nanoemulsion formulations were prepared by constructing pseudo-ternary phase diagrams using lipophilic and hydrophilic surfactants and water. Various mucoadhesive agents were tried out to form thermo-triggered mucoadhesive nanoemulsions. Mucoadhesive gel formula...

in recent decades, most of researchers in pharmaceutical preparations have focused increasingly on new formulations that control the site and amount of drug delivery. mucoadhesive dosage forms are available for systemic or local treatment. the mucoadhesive dosage forms are introduced in various forms such as tablets, gels, ointments, patches and polymeric films. for buccal wound and injury the ...

BACKGROUND AND THE PURPOSE OF THE STUDY The poor bioavailability and therapeutic response exhibited by the conventional ophthalmic solutions due to precorneal elimination of the drug may be overcome by the use of mucoadhesive in situ gel forming systems that are instilled as drops into the eye and undergo a sol-gel transition in the cul-de-sac and have good mucoadhesion with ocular mucus layers...

Aim: The objective of the present study is to design and evaluate mucoadhesive microspheres for oral controlled release. Materials and Method: Rosiglitazone maleate microspheres with a coat consisting of alginate and a mucoadhesive polymer sodium carboxymethylcellulose, carbopol 934P and hydroxypropylmethylcellulose were prepared by an orifice-ionic gelation process. The microspheres were evalu...

Objective: The objective of this research was to formulate and evaluate pectin and HPMC different grades mucoadhesive microspheres in combination with sodium alginate for controlled release of maraviroc. Methods: The maraviroc mucoadhesive microspheres was successfully developed by Ionotropic gelation technique, using sodium alginate, pectin, HPMC K4, K15, and K100 as mucoadhesive polymer in va...

Systemic administration of anticancer drugs is associated with a number of side effects. Therefore, it needs some targeted drug delivery system to deliver the drug which would ensure relief from side effects along with the direct delivery of drug to the site of action in a controlled manner. Keeping in view the importance of mucoadhesive polymers in site specific drug delivery, in the present w...

BACKGROUND Chitosan has gained considerable attentions as a biocompatible carrier to improve delivery of active agents. Application of this vehicle in the form of nanoparticle could profit advantages of nanotechnology to increase efficacy of active agents. The purpose of this study was to provide detailed information about chitosan-glutathione (Cht-GSH)nanoparticles which are gaining popularity...

       In recent decades, most of researchers in pharmaceutical preparations have focused increasingly on new formulations that control the site and amount of drug delivery. Mucoadhesive dosage forms are available for systemic or local treatment. The mucoadhesive dosage forms are introduced in various forms such as tablets, gels, ointments, patches and polymeric films. For buccal wound and inju...

Objective: The objective of the present work was to optimize a rectal suppository containing mucoadhesive pellets Mesalamine achieve local yet sustained release for once-a-day administration therapy Inflammatory Bowel Disease. Methods: Thus, involves forming mesalamine by extrusion spheronization, which were then loaded into be administered rectally. evaluated mucoadhesion strength, swelling po...