Introduction: Diffusion of antibiotic resistance genes by horizontal gene transfer has led to the fast emergence of multidrug resistance (MDR) among bacteria. Multiple classes of integrons are effective genetic elements which play a significant role in the acquisition and nosocomial dissemination of resistance factors in strains of Gram-negative bacteria, Pseudomonas aeruginosa, and Acinetobact...

This study was aimed to find out that broiler chicken farms have problems with antibiotic resistance Citrobacter freundii and determined the prevalence class 1 integron encoding gene. Multidrug collected from among one hundred sixty cloacal swab samples 32 in Blitar for 3 months. The method of bacterial inoculation used MacConkey agar biochemical test conducted by IMViC TSIA test. sensitivity p...

BACKGROUND For the first time we tested an association between the human multidrug resistance gene 1 (MDR1) polymorphisms (SNPs) and idiopathic pulmonary fibrosis (IPF). Several MDR1 polymorphisms are associated with pathologies in which they modify the drug susceptibility and pharmacokinetics. MATERIALS AND METHODS We genotyped three MDR1 polymorphisms of 48 IPF patients and 100 control subj...

background: extended spectrum beta lactamases (esbls) are an important cause of transferable multidrug resistance (mdr) in gram-negative bacteria. the most described esbl genes are generally found within integron-like structures as mobile genetic elements. the aim of this study was to identify the accompanying of class 1 integrons and esbls in the mdr e. coli isolates. methods: susceptibility t...

background and objectives: staphylococcus aureus is a versatile organism causing mild to life threatening infections. the major threat of this organism is its multidrug resistance. the present study was carried out to investigate in - vitro activity of conventional antibiotics routinely prescribed for methicillin resistant s. aureus (mrsa) and methicillin sensitive s. aureus (mssa) infections i...

conclusions this study indicates that satureja khuzestaniea essence has inhibitory effects on the gene expression of antibiotic resistance in bla-oxa-23 that has a high mic. given that this essence has a good inhibitory effect on gene expression in mdr acinetobacter baumannii and bla-oxa-23, the results indicate that it could be used as a natural way to prevent the growth of acinetobacter bauma...

BACKGROUND The adeB gene in Acinetobacter baumannii regulates the bacterial internal drug efflux pump that plays a significant role in drug resistance. The aim of our study was to determine the occurrence of adeB gene in multidrug resistant and New Delhi metallo-beta-lactamase-1 (NDM- 1) gene in imipenem resistant Acinetobacter baumannii isolated from wound swab samples in a tertiary care hospi...

The emergence of multidrug-resistant Enterobacteriaceae strains producing carbapenemases, such as NDM-1, has become a major public health issue due to a high dissemination capacity and limited treatment options. Here we describe the draft genome of three NDM-1-producing isolates: Providencia rettgeri (CCBH11880), Enterobacter hormaechei subsp. oharae (CCBH10892) and Klebsiella pneumoniae (CCBH1...

background carbapenemes are a good choice for treatment of infections caused by multidrug resistant pseudomonads aeruginosa. the emergence of carbapenem resistance has become a major problem in treatment of this organism especially among immunocompromised patients including burn patients. objectives the aim of this study was to investigate carbapenem-resistance mechanisms among burn patients in...