SETTING Kazakhstan is a country with a low HIV/AIDS (human immunodeficiency virus/acquired immune-deficiency syndrome) burden, but a high prevalence of multidrug-resistant tuberculosis (MDR-TB). METHODS We describe the epidemiology of multidrug resistance and HIV among TB patients, using the 2007-2011 national electronic TB register. RESULTS HIV test results were available for 97.2% of TB p...

INTRODUCTION Multidrug-resistant (MDR) Gram-negative healthcare-associated infections are prevalent in Singaporean hospitals. An accurate assessment of the socioeconomic impact of these infections is necessary in order to facilitate appropriate resource allocation, and to judge the costeffectiveness of targeted interventions. MATERIALS AND METHODS A retrospective cohort study involving inpati...

We investigated the prevalence of multidrug resistance, production of extended-spectrum β-lactamases (ESBLs), and presence of class 1 and 2 integrons in 150 clinical isolates of Klebsiella pneumoniae from northwest Iran by performing phenotypic confirmatory tests and polymerase chain reaction (PCR) analysis. Of the 150 isolates, 149 (99.3%) were multidrug resistant (MDR). Of the MDR isolate...

conclusions the result of the current study showed the growing number of nosocomial infections associated with xdr a. baumannii causing difficulties in antibiotic therapy. resistant strains increasingly cause public health problems; therefore, their early detection is essential for healthcare centers. results among the 121 isolated a. baumannii, 44% and 56% were isolated from female and male, r...

conclusions this blis with broad-spectrum activity may be a potential agent for the treatment or control of drug-resistant strains of p. aeruginosa infection. results among the 96 isolates of p. aeruginosa, 2 (2.1%), 94 (97.9%), and 63 (65.6%) were non-mdr, mdr, and xdr, respectively, and 1 (1.1%) was pdr. the most effective antibiotics against these isolates were polymyxins and fosfomycin. a b...

Methods A surveillance module for multidrug resistant bacteria (MDR-KISS) was added to ICU-KISS in 2006. Participating ICUs report data on patients with MRSA, VRE and ESBL bacteria. In contrast to ICU-KISS on nosocomial infections, MDR-KISS documents cases of MDR bacteria including colonization and infection present on admission. MDR-KISS collects the following data: date of ICU-admission and I...

Three independent variants (G2, G4, G5), resistant to methylglyoxal bis(guanylhydrazone), an anticancer drug, have been isolated by single step selection from an adenovirus-transformed rat brain cell line (1). These variants display selective cross-resistance to several natural product drugs of dissimilar structure and action. Multidrug resistance has recently been shown to be caused by overexp...

BACKGROUND AND AIMS Multidrug resistant tuberculosis (MDR-TB) poses problems in treatment, costs and treatment outcomes. It is not known if classically described risk factors for MDR-TB in other countries are the same in Mexico and the frequency of the association between diabetes mellitus (DM) and MDR-TB in our country is not clear. We undertook this study to analyze risk factors associated wi...

Some membrane transporters in liver, such as P-glycoprotein, multidrug resistance-associated protein 2 (MRP2), MRP3, and MRP5 can lead to a complex multidrug resistance (MDR) to antineoplastic agents. How to inhibit these proteins is still an issue. Tetramethylpyrazine is a bioactive constituent isolated from the root of Ligusticum chuanxiong Hort, a Chinese herb. Recent studies showed that it ...