نتایج جستجو برای: murine fibroblast
تعداد نتایج: 155072 فیلتر نتایج به سال:
how to cite this article: wilson md. animal models of cerebral palsy: hypoxic brain injury in the newborn. iran j child neurol. spring 2015; 9(2):9-16. abstract objective hypoxic insults are implicated in the spectrum of fetal disorders, including cerebral palsy (cp). in view of the major contribution of intrapartum risk factors and prematurity to subsequent neurological morbidity and mortality...
The fibroproliferative response to acute lung injury (ALI) results in severe, persistent respiratory dysfunction. We have reported that IL-1beta is elevated in pulmonary edema fluid in those with ALI and mediates an autocrine-acting, fibroblast mitogenic pathway. In this study, we examine the role of IL-1beta-mediated induction of cyclooxygenase-2 and PGE2, and evaluate the significance of indi...
Anti-TNF inhibitors exert their therapeutic effect by inhibition of the excessive amounts TNF-? within body. Recombinant should be produced in a soluble refolded form to investigate effectiveness and efficiency anti-TNF-? compounds. In this research, designed cassette was subcloned pET28a expression vector expressed E. coli BL21 (DE3). The identity protein confirmed through SDS-PAGE Western blo...
Skin fibrosis. Identification and isolation of a dermal lineage with intrinsic fibrogenic potential.
Dermal fibroblasts represent a heterogeneous population of cells with diverse features that remain largely undefined. We reveal the presence of at least two fibroblast lineages in murine dorsal skin. Lineage tracing and transplantation assays demonstrate that a single fibroblast lineage is responsible for the bulk of connective tissue deposition during embryonic development, cutaneous wound hea...
Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis.
Tyrosine kinases play a central role in the activation of signal transduction pathways and cellular responses that mediate the pathogenesis of rheumatoid arthritis. Imatinib mesylate (imatinib) is a tyrosine kinase inhibitor developed to treat Bcr/Abl-expressing leukemias and subsequently found to treat c-Kit-expressing gastrointestinal stromal tumors. We demonstrate that imatinib potently prev...
background one of the main challenges in skin flap surgery is tissue ischemia and following necrosis. the present study compares the effects of fibroblast growth factors 1 and 2 on increasing cutaneous vasculature, improving ischemia, and preventing distal necrosis in ischemic skin flaps in rat model. methods thirty rats were allocated into 3 groups (n=10) and 2×8 cm dorsal random-pattern skin ...
We have introduced the human beta-interferon gene with its promoter region into murine B-cell and fibroblast cell lines via a Moloney murine leukemia virus (M-MuLV) vector and have studied the inducible expression of the beta-interferon gene as a function of the various retroviral vector designs. By deleting the enhancer within the 3' viral long terminal repeat (LTR), inserting the human beta-i...
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