نتایج جستجو برای: mut t2
تعداد نتایج: 31546 فیلتر نتایج به سال:
INTRODUCTION HIV/AIDS is now a global epidemic that has become the leading infectious killer of adults worldwide. Although antiretroviral (ARV) therapy has dramatically improved the quality of life and increased the life expectancy of those infected with HIV but frequency of dosing and drug toxicity as well as the development of viral resistance pose additional limitations. The rapidly expandin...
Alterations in genes involved in the repair of DNA mutations (mut genes) result in an increased mutation frequency and better adaptability of the bacterium to stressful conditions. W-Beijing genotype strains displayed unique missense alterations in three putative mut genes, including two of the mutT type (Rv3908 and mutT2) and ogt. These polymorphisms were found to be characteristic and unique ...
Spread Spectrum CDMA systems suffer from interference in frequency-selective channels. For the uplink, Multiuser Detection (MUD) mitigates the interference. For the downlink, Multiuser Transmission (MUT) is possible, provided that an estimation of the channel impulse response is available. A novel MUT approach is proposed, which outperforms other MUT methods, like Joint Transmission (JT) and di...
Multiuser Transmission (MUT), the counterpart of Multiuser Detection (MUD) in the transmitter, can substantially enhance the performance of the CDMA downlink in frequency-selective channels. Besides linear Multiuser Transmission, known as Joint Transmission and Transmit Wiener filters, recently nonlinear MUT was proposed. The contribution of this paper is the extension of nonlinear Minimum BER ...
The introduction of MAPK pathway inhibitors paved the road for significant advancements in the treatment of BRAF-mutant (BRAF(MUT)) melanoma. However, even BRAF/MEK inhibitor combination therapy has failed to offer a curative treatment option, most likely because these pathways constitute a codependent signaling network. Concomitant PTEN loss of function (PTEN(LOF)) occurs in approximately 40% ...
PURPOSE Blood-based circulating-free (cf) tumor DNA may be an alternative to tissue-based EGFR mutation testing in NSCLC. This exploratory analysis compares matched tumor and blood samples from the FASTACT-2 study. EXPERIMENTAL DESIGN Patients were randomized to receive six cycles of gemcitabine/platinum plus sequential erlotinib or placebo. EGFR mutation testing was performed using the cobas...
Isocitrate dehydrogenase (IDH) mutations are the first mutations that occur during the oncogenic process of lower-grade glioma (LGG) and confers a novel gain-offunction activity by converting a-ketoglutarate (aKG) to 2-hydroxyglutarate (2HG), promoting DNA hypermethylation. Our analysis of LGG cases from The Cancer Genome Atlas (TCGA) database revealed that IDHmutant (IDH-Mut) cases exhibit dec...
The Atmospheric Infrared Sounder (AIRS) on EOS/Aqua platform provides a measurement of global methane (CH4) in the mid-upper troposphere since September, 2002. As a thermal infrared sounder, the most sensitivity of AIRS to atmospheric CH4 is in the mid-upper troposphere with the degree of freedom of ~1.0. Validation of AIRS CH4 product versus thousands of aircraft profiles (convolved using the ...
IgE-mediated allergy to fish is a frequent cause of severe anaphylactic reactions. Parvalbumin, a small calcium-binding protein, is the major fish allergen. We have recently isolated a cDNA coding for carp parvalbumin, Cyp c 1, and expressed in Escherichia coli a recombinant Cyp c 1 molecule, which contained most IgE epitopes of saltwater and freshwater fish. In this study, we introduced mutati...
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