نتایج جستجو برای: myelodysplastic syndrome
تعداد نتایج: 625034 فیلتر نتایج به سال:
The purpose of this review is to provide the most recent data on myelodysplastic syndrome. Haematopoietic disorders, which are stages in process leukaemia development, describe syndromes (MDS). It characterized by aberrant blood cytopenias and cells with unusual appearances, such as macrocytic red hypogranular neutrophils nuclear hyper/hypo segmentation. Due disease's complex pathogenetic chara...
s. 2012;120(21):1696. 73. Itzykson R, Kosmider O, Cluzeau T, et al;Groupe Francophone des Myelodysplasies(GFM). Impact of TET2 mutations on responserate to azacitidine in myelodysplastic syndromesand low blast count acute myeloid leukemias.Leukemia. 2011;25(7):1147-1152. 74. Sekeres MA, List AF, Cuthbertson D, et al.Phase I combination trial of lenalidomide andazacit...
BACKGROUND Patients with chromosome 5 abnormalities and high-risk myelodysplastic syndromes or acute myeloid leukemia have a poor outcome. We hypothesized that increasing doses of lenalidomide may benefit this group of patients by inhibiting the tumor clone, as assessed by fluorescence in situ hybridization for del(5q31). DESIGN AND METHODS Twenty-eight patients at diagnosis or with relapsed ...
Introduction. Myelodysplastic/myeloproliferative neoplasms represent a group of rare hematologic malignancies with concomitant characteristics two different disorders. There are cytopenias and cytoses dysplastic morphology in the circulating blood hyperplastic bone marrow, respectively. Many cytogenetic molecular features have been found this entity, but t(2;11)(p21;q23)del(5) (q22;q33) has not...
Accumulating evidence has shown that marrow failure in some patients with myelodysplastic syndrome is associated with autoimmunity, T-cell mediated myelosuppression and cytokine-induced cytopenias. In this perspective article, Drs. Barrett and Sloand expound on auto-immunity in myelodysplastic syndromes, in particular focusing on what has been learned from study of patients with trisomy 8. See ...
BACKGROUND An alternative reduced-toxicity conditioning regimen for allogeneic transplantation, based on treosulfan and fludarabine, has recently been identified. The rationale for this study was to investigate the efficacy and safety of this regimen prospectively in patients with a primary myelodysplastic syndrome. DESIGN AND METHODS A total of 45 patients with primary myelodysplastic syndro...
BACKGROUND Transfusion-dependency affects the natural history of myelodysplastic syndromes. Secondary iron overload may concur to this effect. The relative impact of these factors on the outcome of patients with myelodysplastic syndrome receiving allogeneic stem-cell transplantation remains to be clarified. DESIGN AND METHODS We retrospectively evaluated the prognostic effect of transfusion h...
BACKGROUND This is a rare instance of acute kidney injury caused by hyperuricemia due to spontaneous tumor lysis syndrome and also the first case of spontaneous tumor lysis syndrome reported in association with myelodysplastic syndrome. CASE PRESENTATION A 53-year-old man presented with abrupt oliguria. Laboratory findings on admission included hyperuricemia, hyperphosphatemia, hypocalcemia, ...
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