Myeloid sarcomas are tumor masses composed of aggregates of malignant myeloid precursors in extramedullary sites including the skin. We report a case of myeloid sarcoma in a patient who presented with an ear lobe mass and facial nerve paralysis. Expression of CD56 by the malignant cells led to an initial misdiagnosis as Merkel cell tumor. Comprehensive pathological evaluation confirmed the diag...

Myeloid sarcoma is a rare tumor mass with extra medullary growth pattern, composed of myeloblast or immature myeloid cells. (MS) distinct clinical presentation acute leukemia (AML) where less than 1% patients present prominent disease which most commonly involves the bone, skin, lymph node, soft tissues, gastrointestinal tract testes. The recommended treatment regimen in isolated bone marrow in...

The aim of this study was to determine the myeloid-related protein-8 and myeloid-related protein-14 levels in the gingival crevicular fluid of smoker patients with generalized aggressive periodontitis (SAgP), smoker patients with chronic periodontitis (SCP), smoker patients with gingivitis (SG-smoker control), non-smoker patients with generalized aggressive periodontitis (AgP), non-smoker patie...

Myeloid cells are critically involved in the pathophysiology of cancers. In the tumor microenvironment (TME), they comprise tumor-associated macrophages (TAMs), neutrophils (TANs), dendritic cells, and myeloid-derived suppressor cells, which are further subdivided into a monocytic subset and a granulocytic subset. Some of these myeloid cells, in particular TAMs and TANs, are divided into type 1...

The dynamic interplay between tumor cells and immune in the microenvironment plays a crucial role determining disease severity therapeutic outcome cancer. Myeloid are most abundantly available cell population microenvironment. have been shown to exist diverse phenotypes play both antitumoral protumoral roles Understanding biology of myeloid can lay foundation for development strategies aimed at...

Abstract Myeloid‐derived suppressor cells (MDSCs) refer to a group of immature myeloid with potent immunosuppressive capacity upon activation by pathological conditions. Because their ability, MDSCs have garnered extensive attention in the past few years fields oncology, infection, chronic inflammation and autoimmune diseases. Research on liver diseases has gradually increased, potential therap...

Id proteins are helix-loop-helix (HLH) transcriptional factors that lack the basic DNA binding domain. The Id proteins have been reported generally to function as inhibitors of cell differentiation, and their gene expression is often downregulated during cell differentiation. We examined the expression of human Id mRNAs by Northern hybridization in 11 human myeloid cell lines, several myeloid c...

BACKGROUND The hypocellular variant of acute myeloid leukemia accounts for less than 10% of all cases of adult acute myeloid leukemia. It is defined by having less than 20 percent of cellular bone marrow in a biopsy at presentation. It is unclear in the literature whether the outcome of hypocellular acute myeloid leukemia differs from that of non-hypocellular acute myeloid leukemia. DESIGN AN...

Zbtb1 is a transcription factor that prevents DNA damage and p53-mediated apoptosis in replicating immune progenitors, affecting lymphoid as well as myeloid development when hematopoietic progenitors are in competition in mixed bone marrow chimeras. However, Zbtb1-deficient mice do not have an apparent myeloid deficiency. We report here that Zbtb1-deficient lymphoid-primed multipotent progenito...

The clinical relevance of myeloid antigen expression in childhood ALL as prognostic factor remains controversial. Some studies showed that children with myeloid-positive ALL had a poorer clinical outcome compared with those of meloid-negative ALL patients. In our population, myeloid antigen was expressed in 25% of ALL patients. They were treated with Indonesia 2006 ALL protocol. ABSTRACT The fr...