3,5-Disubstituted hydantoin (1,3-imidazolidinedione) derivatives 5a-h were prepared by base induced cyclization of the corresponding N-(1-benzotriazolecarbonyl)-L- and D-amino acid amides 4a-h. Compounds 5a-h were evaluated for their cytostatic and antiviral activities. Among all the compounds evaluated, 3-benzhydryl-5-isopropyl hydantoin (5a) showed a weak but selective inhibitory effect again...

Multidrug resistance has become a factor seriously limiting treatment of various diseases, including bacterial (1ñ3) and fungal (4) infections and cancer (5ñ7). The major mechanism of multidrug resistance (MDR) in cancer is the over-expression of ATP-dependent drug-efflux pumps (drug transporters), which reduces the accumulation of agents. One of the most important mechanisms of MDR in cancer i...

In 1912 Lewis (1) administered hydantoin to rabbits, cats, and dogs and came to the conclusion that the ring was not readily broken in the body. Gaebler and Keltch (2) some years later showed that some hydantoin was excreted as hydantoic acid after injection into dogs. Wada (3) claimed that urea was produced from hydantoin after incubation with milk or certain tissue suspensions. Finally, Kozel...

The gene hyuP from Microbacterium liquefaciens AJ 3912 with an added His6 tag was cloned into the expression plasmid pTTQ18 in an Escherichia coli host strain. The transformed E. coli showed transport of radioisotope-labeled 5-substituted hydantoins with apparent K(m) values in the micromolar range. This activity exhibited a pH optimum of 6.6 and was inhibited by dinitrophenol, indicating the r...

The hydantoin racemase gene of Pseudomonas sp. strain NS671 had been cloned and expressed in Escherichia coli. Hydantoin racemase was purified from the cell extract of the E. coli strain by phenyl-Sepharose, DEAE-Sephacel, and Sephadex G-200 chromatographies. The purified enzyme had an apparent molecular mass of 32 kDa as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. ...

Uranium nitride complexes are attractive targets for chemists as molecular models the bonding, reactivity, and magnetic properties of next-generation nuclear fuels, but these molecules uncommon can be difficult to isolate due their high reactivity. Here, we describe synthesis three new multinuclear uranium complexes, [U(BCMA)2]2(μ-N)(μ-κ1:κ1-BCMA) (7), [(U(BIMA)2)2(μ-N)(μ-NiPr)(K2(μ-η3:η3-CH2CH...

Hydantoin derivatives are commonly used anticonvulsants. In general, they effective for partial-onset seizures and tonic-clonic seizures, but not absence seizures. Phenytoin is the most important drug in this group, other drugs, ethotoin, mephenytoin, also to treat epilepsy. Prodrugs such as have been created. some cases of trigeminal neuralgia related neuralgia. arrhythmias. Hydantoins or glyc...