Nail beading has previously been reported as an accompaniment of rheumatoid arthritis. In order to assess the clinical significance of this form of nychodystrophy the fingernails and toenails of 119 patients with rheumatoid arthritis and an equal number of control subjects were studied. Analysis of data based on 4642 nails indicates that the presence of a global pattern of beading (i.e. greater...

Congenital onychodysplasia of the index fingers, also known as Iso–Kikuchi syndrome, is characterized using five diagnostic criteria: congenital occurrence, unilateral or bilateral involvement of the index fingers, variation in nail appearance, possible hereditary involvement and frequently associated bone abnormalities1–5. Herein, we present the case of a newborn with congenital onychodysplasi...

SUMMARY Since Farvardin 1366 to Esfand 1367 (March 1987 to March 1989) more than 60 psoriatic patients hospitalized in Loghman Hakim Medical Center were evaluated for age, sex, place of birth, morphology of psoriatic lesion, . duration of the disease, association with arthropathy, sensitivity to light, nail involvement, history ofinkction, emotional stress and family history, also scrum calciu...

BACKGROUND Previous clinical trials have not evaluated improvement in nail psoriasis as a primary end point. OBJECTIVE This phase 3 trial evaluated the safety and efficacy of adalimumab in patients with moderate-to-severe fingernail psoriasis and moderate-to-severe plaque psoriasis. METHODS Patients were randomized 1:1 to 40 mg adalimumab every other week or placebo. The primary efficacy en...

Pigmented and non-pigmented nail alterations are a frequent challenge for dermatologists. A profound knowledge of clinical and dermatoscopic features of nail disorders is crucial because a range of differential diagnoses and even potentially life-threatening diseases are possible underlying causes. Nail matrix melanocytes of unaffected individuals are in a dormant state, and, therefore, fingern...

BACKGROUND The prevalence and clinical characteristics of psoriatic arthritis (PsA) in patients with psoriasis are not well described in Asian populations, including Koreans. OBJECTIVE The purpose of this study was to investigate the prevalence of PsA by using the classification of psoriatic arthritis (CASPAR) criteria on the basis of physical examination only, as well as its correlation with...

Psoriasis is a chronic inflammatory disease affecting up to 3% of the general population. The prevalence of nail involvement in psoriasis patients varies between 15% and 79%. While the nails represent a small portion of the body surface area, psoriasis in these areas can have a disproportionate influence on a patient's physical and psychosocial activities. Differential diagnosis between an onyc...