Self-assembled nanomedicines offer a versatile approach for developing effective cancer treatments. In article number 2000159, Horacio Cabral and co-workers review the recent progress of self-assembled in clinical studies. Moreover, lessons learned from these studies immediate challenges are discussed.

Nanomedicines based on poly(lactic-co-glycolic acid) (PLGA) carriers offer tremendous opportunities for biomedical research. Although several PLGA-based systems have already been approved by both the Food and Drug Administration (FDA) European Medicine Agency (EMA), are widely used in clinics treatment or diagnosis of diseases, no PLGA nanomedicine formulation is currently available global mark...

The development of functional lipid nanoparticles (LNPs) is one the major challenges in field drug delivery systems (DDS). Recently, LNP-based RNA systems, namely, RNA-loaded LNPs have attracted attention for therapy. In particular, mRNA-loaded LNP vaccines were approved to prevent COVID-19, thereby leading paradigm shift toward next-generation nanomedicines. For nanomedicines, size a significa...

Balancing surface functionalization and low immune recognition of nanomedicines is a major challenge. Opsonization with the third component of the complement protein (C3) plays a major role in immune cell recognition of nanomedicines. We used dextran-coated superparamagnetic iron oxide nanoworms (SPIO NWs) to study the effect of surface functionalization on C3 opsonization in mouse serum and su...

Cancer continues to remains a major healthcare problem across the world despite strong translational research efforts towards tackling the disease. Surgery, when possible, along with radiation and chemotherapy continue to remain the mainstay of cancer treatment. Novel targeted therapies or biologics and immunotherapies have recently been approved to improve treatment efficacies while reducing c...

High-throughput production of nanoparticles (NPs) with controlled quality is critical for their clinical translation into effective nanomedicines for diagnostics and therapeutics. Here we report a simple and versatile coaxial turbulent jet mixer that can synthesize a variety of NPs at high throughput up to 3 kg/d, while maintaining the advantages of homogeneity, reproducibility, and tunability ...

Therapeutic and diagnostic nanomaterials are being intensely studied for several diseases, including cancer and atherosclerosis. However, the exact mechanism by which nanomedicines accumulate at targeted sites remains a topic of investigation, especially in the context of atherosclerotic disease. Models to accurately predict transvascular permeation of nanomedicines are needed to aid in design ...