Nabumetone is a nonacidic nonsteroidal anti-infl ammatory drug (NSAID) formulated as a pharmacologically inactive prodrug that becomes active only after absorption, predominantly in the small intestine, and through hepatic conversion to its active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA). This metabolite is structurally similar to naproxen, and is a potent inhibitor of prostaglandin ...

Nonsteroidal anti-inflammatory drugs have been reported to exacerbate hypertension. In this study, we tested the hypothesis that a nitric oxide-releasing derivative of naproxen would ameliorate hypertension in the rat. Hypertension was induced by partially occluding one renal artery (the "2K,1C" model), and 2 wk later the rats started receiving naproxen, the nitric oxide-releasing derivative HC...

OBJECTIVE To compare the three non-steroidal anti-inflammatory agents (NSAIDs) Diclofenac potassium, Etodolac and Naproxen sodium in relation to pain, swelling and trismus following impacted third molar surgery. STUDY DESIGN The study was a randomized and a double-blinded study which included 42 healthy young individuals with impacted third molars and bone retention. Patients were randomly as...

OBJECTIVES : Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for the treatment of pain in chronic pancreatitis (CP). This study aimed to investigate the effect of NSAIDs on the inflammation and fibrosis progression in trinitrobenzene sulfonic acid-induced CP rats. METHODS Chronic pancreatitis was induced by trinitrobenzene sulfonic acid infusion into rat pancreatic ducts. ...

a three-fold decrease of the in vitro ability of serum proteins to bind naproxen was shown in patients with cirrhosis of the liver compared to healthy individuals. this decrease was caused by quantitative changes in serum proteins in the sera of patients with liver damage. lower doses of naproxen are therefore suggested in the treatment of patients with liver dysfunction.

Introduction: Effective post-operative pain management is one of the problems following root canal treatment. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly prescribed analgesics in endodontics. The aim of this study was to evaluate the effectiveness of naproxen in controlling pain following root canal treatment in teeth with irreversible pulpitis. Materials and methods: Th...

Crystal structures are presented for two dihydrate polymorphs (DH-I and DH-II) of the non-steroidal anti-inflammatory drug sodium (S)-naproxen. The structure of DH-I is determined from twinned single crystals obtained by solution crystallization. DH-II is obtained by solid-state routes, and its structure is derived using powder X-ray diffraction, solid-state (13)C and (23)Na MAS NMR, and molecu...

Meloxicam is a new non-steroidal anti-inflammatory drug (NSAID) which preferentially inhibits cyclooxygenase-2 over cyclooxygenase-1. A double-blind parallel-group trial compared meloxicam 7.5 mg once daily (n = 199) with naproxen 750 mg (n = 180) in rheumatoid arthritis. There was no significant difference between the groups regarding the primary efficacy variables (global efficacy assessment ...

Objectives: To evaluate the gastrointestinal safety and efficacy of the COXinhibiting nitric oxide donator (CINOD) AZD3582 [4-(nitrooxy)butyl-(2S)-2-(6methoxy-2 naphthyl)propanoate] in patients with hip or knee osteoarthritis. Methods: Patients (n=970) enrolled into a double-blind study were randomised (7:7:2) to AZD3582 750 mg twice daily, naproxen 500 mg twice daily or placebo twice daily. Th...