نتایج جستجو برای: nasal administration
تعداد نتایج: 276588 فیلتر نتایج به سال:
choanal polyps are a form of nasal polyps that grow toward the choana with a single stalk. septochoanal polyp is a rare entity that originates from the mucosa of the nasal septum with choanal extension. the most common site of its origin is mainly the superior aspect of the posterior portion of the nasal septum. however, metaplastic ossification is a rare event in nasal polyp and to the best of...
Nasal application of benzodiazepines might be an alternative to intravenous administration in acute clinical situations such as seizures emergencies. However, irritation and pain as well as symptoms like teary eyes, dizziness, discomfort, nasal drainage and bad taste usually accompany subject received midazolam and diazepam via the nasal route. The purpose of this study was to evaluate the use ...
Intranasal route, ensuring suitable bioavailability of medicines under circumvention of the gastrointestinal degradation and hepatic first-pass elimination, has been a popular choice for drug delivery. Among nasal dosage forms, mucoadhesive solid inserts have been shown to resist mucociliary clearance and provide a prolonged nasal residence time. Hence, the purpose of this study was the prepara...
prolonged residence of drug formulation in the nasal cavity is important for the enhancing intranasal drug delivery. the objective of the present study was to develop a mucoadhesive in-situ gelling nasal insert which would enable the reduced nasal mucociliary clearance in order to improve the bioavailability of metoclopramide hydrochloride. metoclopramide hydrochloride is a potent antiemetic an...
INTRODUCTION Mechanical trauma to the nasal mucosa increases the risk of synechia formation, especially after chronic rhinosinusitis and nasal surgeries. OBJECTIVE This study was carried to assess the effect of propolis administration in healing injured nasal mucosa in rats. METHODS We randomly divided eighteen rats into three equal experimental groups: (1) non-treated group; (2) gum tragac...
The nasal absorption of macromolecules from powder formulations and the effect of sodium carboxymethyl cellulose (CMC-Na) as a pharmaceutical excipient on their absorption were studied. Model macromolecules were fluorescein isothiocyanate-labeled dextran (average molecular weight of 4.4kDa, FD4) and insulin. The plasma concentration of FD4 after application of the powder containing 50% starch (...
Nasal administration is an effective route for a needle-free vaccine. However, nasally administered Ags have the potential to reach the CNS directly from the nasal cavity, thus raising safety concerns. In this study, we performed real-time quantitative tracking of a nasal vaccine candidate for botulism, which is a nontoxic subunit fragment of Clostridium botulinum type A neurotoxin (BoHc/A) eff...
Address for correspondence Mr. Arshad Bashir Khan, Associate Professor, Department of Pharmaceutics, Krupanidhi College of Pharmacy, #12/1, Chikkabellandur Village, Carmelaram Post Varthur Hobli, Bangalore-560035, India. Phone No: 9740379897 E-mail: [email protected] ABSTRACT Purpose: This review article focuses on providing updated information about targeting the nasal mucosa for drug delivery....
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید