AIM To observe the frequency of nasopharyngeal carcinoma (NPC) and its association with Epstein Barr Virus (EBV) infection. SETTING This study included consecutive cases of nasopharyngeal carcinoma, which were diagnosed in the Department of Pathology at the Aga Khan University Hospital, Karachi in the period of two years (1996-97). METHODS These tumors were initially evaluated on H&E staine...

Nasopharyngeal carcinoma (NPC) is a tumor arising from the epithelial cells that cover the surface and line the nasopharynx. The annual incidence of NPC in the UK is 0.3 per million at age 0-14 years, and 1 to 2 per million at age 15-19 years. Incidence is higher in the Chinese and Tunisian populations. Although rare, NPC accounts for about one third of childhood nasopharyngeal neoplasms. Three...

Serological detection of Epstein-Barr virus (EBV) antibodies is frequently used in nasopharyngeal carcinoma (NPC) mass screening. However, the large number of seropositive subjects who require close follow-up is still a big burden. The present study aimed to detect the nasopharyngeal EBV load in a high-risk population seropositive for antibodies against EBV, as well as to examine whether assay ...

BACKGROUND Cyclooxygenase 2 (COX-2), an inducible prostaglandin synthase, participates in inflammatory and neoplastic processes. It is expressed by various tumours and contributes to carcinogenesis. Notably, COX-2 inhibitors appear to have tumour suppressor effects and are being evaluated in clinical trials. AIMS To investigate COX-2 expression in nasopharyngeal carcinoma (NPC), a common tumo...

Centipeda minima is a medicinal plant reputed in China as a remedy for nasopharyngeal carcinoma (NPC). In this study, bioactivity-guided fractionation of the anti-NPC compound(s) from C. minima led to the isolation of 2beta-(isobutyryloxy)florilenalin (IF), a sesquiterpene lactone. IF showed significant dose- and time- dependent inhibition on the growth of the human nasopharyngeal carcinoma epi...

Although Epstein-Barr virus-associated nasopharyngeal carcinoma (NPC) is a highly radiosensitive cancer, approximately 20% of patients with NPC develop local recurrence after radiation therapy. Multiple proinflammatory cytokines are thought to protect NPC tumor cells from immune surveillance and therapeutic interventions. The cytokine leukemia inhibitory factor (LIF) is a critical component of ...

Nasopharyngeal carcinoma (NPC) is an epithelial malignancy that is specifically endemic in Southern China (age-standardized incidence rate: ASR = 30-50/105 per year) and Southeast Asia (ASR = 9-12/105 per year) but it is uncommon in the rest of the world (McDermott et al., 2001). NPC is one of the top ten cancers in Thailand (ASR = 3-10 /105 per year) and causes dramatical loss of human resourc...

Human leukocyte antigen G (HLA-G) has multiple immune regulatory functions including the induction of immune tolerance in malignancies. The roles of HLA-G have not been investigated in nasopharyngeal carcinoma (NPC). This study is aimed to evaluate the role of HLA-G as prognostic factor for NPC patients as well as its role in the immune regulation. Western assays showed high HLA-G expression in...

Introduction: Nasopharyngeal carcinoma (NPC) is the most common head and neck malignancy in Indonesia ranks it as fourth among all malignancies Indonesia. In Indonesia, estimated that incidence of NPC 6.2 per 100,000 population or 12,000 new cases year. The initial stage difficult to establish because location hidden nasopharynx. Misdiagnosis often results from a lack knowledge about early sign...

The invasion and metastasis processes involved in nasopharyngeal carcinoma (NPC) remain enigmatic. Transient receptor potential channel-related protein 1 (TRPC1) is a cation channel involved in diverse cellular functions by precisely controlling Ca2+. The role of this unique TRPC member in nasopharyngeal malignancies has not yet been delineated. H...