Secondary metabolites (or natural products) are often synthesized by multi-modular, multi-domain proteins called non-ribosomal peptide synthetases (NRPS) and polyketide synthases (PKS). Various well-known metabolites produced by microorganisms are listed in Table 1, and examples of structures are shown in Fig. 1. In particular, Streptomyces species are known for their ability to produce a wide ...

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Acquired immunodeficiency syndrome (AIDS), caused by human immunodeficiency virus (HIV), is an immunosuppressive disease that results in life-threatening opportunistic infections and malignancies. Despite continuous advances made in antiretroviral therapy, AIDS has become the leading cause of death in Africa and fourth worldwide; the number of people with HIV is increasing at an alarming rate i...

Researchers in the post-genome era are confronted with the daunting task of assigning structure and function to tens of thousands of encoded proteins. To realize this goal, new technologies are emerging for the analysis of protein function on a global scale, such as activity-based protein profiling (ABPP), which aims to develop active site-directed chemical probes for enzyme analysis in whole p...

This review covers the 390 novel marine natural products described to date from deep-water (>50 m) marine fauna, with details on the source organism, its depth and country of origin, along with any reported biological activity of the metabolites. Relevant synthetic studies on the deep-sea natural products have also been included.

Bioactive marine natural products can be defined as biologically active products, both secondary metabolites as well as enzymes, lipids and heteropolysaccharides derived from marine sources. Marine natural products have been found to be an important source of drugs and drug leads. These natural products are secondary metabolites and enhance survival fitness and may serve as chemical weapons use...

1 Department of Pharmacognosy, Faculty of Pharmaceutical Science, Nagasaki International University, Sasebo, Nagasaki 859-3298, Japan 2 Pritzker School of Medicine, University of Chicago Medicine, 5841 S. Maryland Avenue, Chicago, IL 60637, USA 3 School of Pharmacy, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China 4Department of Human Morphology, Semmelweis University, H-1085 Budape...

A wound is a disruption of the normal anatomical structure and function of a tissue. Wounds cure in an orderly and timely repair process which is characterized by three dynamic and interactive phases: inflammation, proliferation and the remodeling. The present review was designed to elaborate the cellular and molecular targets for plant secondary metabolites that target the various aspects of w...

Recent research on the chemistry of natural products from the author's group that led to the receipt of the ACS Ernest Guenther Award in the Chemistry of Natural Products is reviewed. REDOR NMR and synthetic studies established the T-taxol conformation as the bioactive tubulin-binding conformation, and these results were confirmed by the synthesis of compounds which clearly owed their activity ...