project planning is part of project management, which is relates to the use of schedules such as gantt charts to plan and subsequently report progress within the project environment. initially, the project scope is defined and the appropriate methods for completing the project are determined. in this paper a new approach for the critical path analyzing a project network with random fuzzy activi...

Voltage-gated sodium (NaV) channels are membrane proteins that consist of 24 transmembrane segments organized into four homologous domains, and are essential for action potential generation and propagation. Although the S6 helices of NaV channels line the ion conducting pore and participate in channel activation, their functional architecture is incompletely understood. Our recent studies show ...

NaChBac was the first discovered bacterial sodium voltage-dependent channel, yet computational studies are still limited due to the lack of a crystal structure. In this work, a pore-only construct built using the NavMs template was investigated using unbiased molecular dynamics and metadynamics. The potential of mean force (PMF) from the unbiased run features four minima, three of which corresp...

Several subtypes of voltage-gated Na+ (NaV) channels are important targets for pain management. μ-Conotoxins isolated from venoms of cone snails are potent and specific blockers of different NaV channel isoforms. The inhibitory effect of μ-conotoxins on NaV channels has been examined extensively, but the mechanism of toxin specificity has not been understood in detail. Here the known structure ...

Bisphenol A (BPA) has attracted considerable public attention as it leaches from plastic used in food containers, is detectable in human fluids and recent epidemiologic studies link BPA exposure with diseases including cardiovascular disorders. As heart-toxicity may derive from modified cardiac electrophysiology, we investigated the interaction between BPA and hNav1.5, the predominant voltage-g...

0

project scheduling   net present value   we consider a project scheduling problem with permitted tardiness and discrete time/resource trade-offs under maximum net present value objective. in this problem, a project consists of a set of sequential phases such that each phase contains one or more sub-projects including activities interrelated by finish-start-type precedence relations with a time ...

the aim of this paper is to highlight the issue of managerial competencies and competency model in industrial enterprises. this paper builds upon the theory of knowledge processing and its role as a theoretical basis for knowledge development in the area of managerial competencies. managerial competencies are becoming one of the key building blocks of success in a company to achieve both the mi...