C harcot-Marie-Tooth (CMT) disease is a clinically and genetically heterogeneous group of disorders that involve the peripheral nervous system. It is characterised by progressive distal neurogenic muscular atrophy and weakness that initially affects the peroneal muscles and later the hands. Charcot-Marie-Tooth disease type 1 (CMT1), also called hereditary motor and sensory neuropathy type I (HM...

Renewable active sludge is a smart material for wastewater treatment and the protection of surface water bodies. The generated pellets (dried pelletised dehydrated anaerobically stabilised excess sludge) are produced in quantity 31.4 ± 5.6 g dry matter (DM) per one Population equivalent (PE) calculated to COD (PECOD) day. As combustible material, their energy utilisation must reach sustainable ...

Abstract Exercise echocardiography (ExE) can predict overall and cardiovascular mortality. We aimed to assess the value of imaging functional capacity by ExE for prediction (CV), cancer (CA) non-cardiovascular non-cancer (NCV-NCA) death in senior people. Methods Retrospective analysis prospectively collected data on 1,826 patients aged ≥75 years (79±3 years, 44% women) with a first treadmill pe...

OBJECTIVE The aim of the present study was to investigate any relationship between serum ubiquitin levels and electroneurographic changes in peripheral nerves for patients with type 2 diabetes. RESEARCH DESIGN AND METHODS The study involved 34 patients (19 men, 15 women; mean age 46 +/- 13 years) with type 2 diabetes. Serum ubiquitin values were measured by sandwich enzyme-linked immunosorben...

OBJECTIVES To examine the effect of occupational exposure to cyclohexane on the peripheral nervous system. METHODS A nerve conduction study was performed on 18 workers exposed to cyclohexane in a luggage factory and on age and sex matched occupationally unexposed controls. 12 workers had been exposed to n-hexane (median 2.8 years) before the start of exposure to cyclohexane. To confirm the ef...

abstract objective autosomal recessive spinal muscular atrophy (sma) is, after cystic fibrosis, the second most common fatal monogenic disorder and the second most common hereditary neuromuscular disease after duchenne dystrophy. the disease is characterized by degeneration of anterior horn cells leading to progressive paralysis with muscular atrophy. depending on the clinical type (werdnig- ho...

introduction: arteriovenous fistulas (avf) make chronic hemodialysis easy, but the complications are unpredictable. ischemic neuropathy due to arterial insufficiency is one of the most important complications of avf. this study was designed to evaluate ischemic neuropathy using electro diagnostic method in the extremity carrying fistula. methods: in this cross-sectional study, 37 hemodialysis p...

High-dimensional binary classification tasks, e.g. the classification of mi-croarray samples into normal and cancer tissues, usually involve a tuning parameter adjusting the complexity of the applied method to the examined data set. By reporting the performance of the best tuning parameter value only, over-optimistic prediction errors are published. The contribution of this paper is twofold. Fi...

Peripheral sensory neuropathy and its risk factors are well-described in adults with type 1 diabetes (T1D). While clinically evident neuropathy is rare in young people with T1D, we and others have shown that subclinical peripheral neuropathy is common [1]. However, the prevalence of sensory neuropathies may be underestimated, due to a lack of established testing guidelines. We performed a syste...

Oxidative stress and neurovascular dysfunction have emerged as contributing factors to the development of experimental diabetic neuropathy (EDN) in streptozotocin-diabetic rodents. Additionally, depletion of C-peptide has been implicated in the pathogenesis of EDN, but the mechanisms of these effects have not been fully characterized. The aims of this study were therefore to explore the effects...