In sepsis, both necrotic and apoptotic cell death can occur. Apoptotic cells induce anergy that could impair the host response, whereas necrotic cells cause immune activation that might result in enhanced antimicrobial defenses. We determined whether adoptive transfer of apoptotic or necrotic cells impacted survival in a clinically relevant sepsis model. We also evaluated the effects of adoptiv...

Viral and bacterial associations appear to be implicated in the development of periodontal infections. Little information is available describing the periodontopathic agents in root canals with necrotic pulp. In this study, the occurrence and the combinations among herpes simplex virus type 1 (HSV-1) and Dialister pneumosintes, Tannerella forsythia, and Treponema denticola in patients with chro...

High mobility group box-1 (HMGB1) is extracellularly released from mononuclear phagocytes by lipopolysaccharide (LPS)-stimulation accompanied with cell death, and plays an important role in septic/endotoxin shock as a late phase mediator. Notably, CAP11 (cationic antibacterial polypeptide of 11-kDa), a member of cathelicidin family of antimicrobial peptides, has a potential to bind with LPS and...

Abstract Glioblastoma (GBM) is the most common and malignant primary brain tumor with pre-necrotic post-necrotic growth phases. The development of necrosis associated extensive micro-environmental (TME) rearrangement rapid biologic advancement. Compared to GBMs, GBMs are heterogenous contain multi-focal regions surrounded by pseudopalisading cells characterized severe hypoxia. Hypoxic, peri-nec...

Necrotic enteritis has until recently been considered an infections disease of swine caused by the micro-organism Salmonella eholeraesuis. Lately, however, the relation of swine nutrition to the development of this disease has been given prominent attention. The results of investigations now in progress in different sections of the country may clarify the question of the cause of the disease. N...

We report a case of a rare complication of laparoscopic adjustable gastric banding (LAGB) as a cause of death in the immediate post-operative period. The number of relevant reports and postmortem images presented in the literature is extremely restricted. Gastric necrosis may constitute a cause of death after LAGB in the early post-operative period. Postmortem examination reveals the extension ...

Morphological features of lesions conforming to the description of solitary necrotic nodules of the liver were compared with liver haemangiomata and necrotic tumour metastases in the liver. An origin in haemangiomata is confirmed for most of the lesions studied, although the necrotic nodule may represent the end stage of a variety of lesions. These lesions are usually benign, although necrotic ...