Previously this laboratory characterized Slc39a8-encoded ZIP8 as a Zn(2+)/(HCO(3)(-))(2) symporter; yet, the overall physiological importance of ZIP8 at the whole-organism level remains unclear. Herein we describe the phenotype of the hypomorphic Slc39a8(neo/neo) mouse which has retained the neomycin-resistance gene in intron 3, hence causing significantly decreased ZIP8 mRNA and protein levels...

Media, during Taliban five years period from 1996-2001, had been totally suffocated. Only limited number of print media would publish to spread the propaganda Emirate under Sharia Law. Post-Taliban era, landscape obtained new image with establishment democratic government. Independent were allowed operate in accordance formation constitution 2004. Afghanistan rise and promote voice right, equal...

IntroductionOn August 15, 2021, the Taliban marked a turning point in history of Afghanistan by seizing power for second time and announcing an interim government Kabul. Their first victory capture Kabul led to regime that lasted

The events of 9/11 2001 led the United States to issue a Global War on Terror (GWOT) policy. One implementation this policy is war against Al-Qaeda groups under Taliban regime in Afghanistan. U.S. has launched several attacks Taliban, killing many soldiers and civil society region. After decades fighting with military force, ultimately signed peace treaty February 29, 2020. Although still at fo...

Afghanistan’s Taliban are back in power. How did they get there? can their discriminatory policies be explained? And what done about it? The article looks at the failure of international engagement Afghanistan from 2001 to 2021 and dynamics that enabled reemerge. Having gained control country again August 2021, unpacks way govern populations, how decisions made within divided movement, its high...

After the 9/11 attacks, The United States of America (USA) destroyed al Qaeda’s established training bases and removed the Taliban from power in Afghanistan. Thus, al Qaeda is forced to find new havens to continue operating safely as well as new sources of recruits. Unfortunately, if the conditions in the ground do not change, West Africa will be the next recruiting front for Osama bin Laden’s ...

This paper outlines the implications of international approaches to humanitarian assistance in Afghanistan, focusing in particular on the period since the Taliban assumed power. It argues that international efforts to use conditionality on humanitarian assistance have proved ineffective in influencing the Taliban's policies, and have been implemented despite the negative impact on the welfare o...

OBJECTIVES We sought to assess the prevalence and progression of neo-aortic root dilation and valvar regurgitation after staged reconstruction for hypoplastic left heart syndrome (HLHS). BACKGROUND In HLHS, the pulmonary valve functions as the neo-aortic valve. Neo-aortic valve dysfunction has been observed after arterial switch operation and the Ross procedure. METHODS Patients with HLHS b...

Cell cycle checkpoints are evolutionarily conserved signaling pathways that uphold genomic integrity. Complete inactivation of the mouse checkpoint gene Hus1 results in chromosomal instability, genotoxin hypersensitivity, and embryonic lethality. To determine the functional consequences of partial Hus1 impairment, we generated an allelic series in which Hus1 expression was incrementally reduced...