نتایج جستجو برای: neoadjuvant chemoradiation

تعداد نتایج: 18874  

Journal: :گوارش 0
payam azadeh ali motlagh abdollah fazlalizadeh azim arbabi behrouz shafaghi mohammad fudazi

background: oxaliplatin (ox) significantly enhanced the antitumor activity of 5-fu in patients with advanced colorectal cancer and recently some phase ii trials have evaluated the feasibility and efficacy of oxaliplatin in neoadjuvant setting for treatment of locally advanced rectal cancer. on the other hand various studies have demonstrated that the overexpression of thymidylate synthase (ts) ...

2004
Sheikh Hasibur Rahman Robin Urquhart Michele Molinari

The use of neoadjuvant therapies has played a major role for borderline resectable and locally advanced pancreatic cancers (PCs). For this group of patients, preoperative chemotherapy or chemoradiation has increased the likelihood of surgery with negative resection margins and overall survival. On the other hand, for patients with resectable PC, the main rationale for neoadjuvant therapy is tha...

Journal: :Archives of surgery 2003
Karlheinz Ammann Werner Kirchmayr Alexander Klaus Gilbert Mühlmann Reinhold Kafka Michael Oberwalder Alexander De Vries Dietmar Ofner Helmut Weiss

HYPOTHESIS Preoperative chemoradiation for patients with stage II and III midrectal and low rectal cancer may improve survival and decrease local recurrence rate. We evaluated the long-term impact of neoadjuvant chemoradiation on anal sphincter function. DESIGN Prospective analysis. SETTING Tertiary referral center. PATIENTS From March 1, 1996, to January 31, 2002, 50 patients with midrec...

Journal: :Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti 2014
I Richter J Dvořák J Bartoš

Rectal adenocarcinoma, in contrast to colorectal carcinoma, is typical of its high local reccurence rate. Radiotherapy is proved to reduce the incidence of recurrences. Neoadjuvant chemoradiotherapy demonstrated better treatment results than adjuvant chemoradiotherapy. Standard cytotoxic agents involved in combination therapy are 5- flurouracil or capecitabin. Epidermal growth factor receptor (...

Journal: :The oncologist 2014
Kathleen K Christians Susan Tsai Anna Mahmoud Paul Ritch James P Thomas Lauren Wiebe Tracy Kelly Beth Erickson Huamin Wang Douglas B Evans Ben George

BACKGROUND Borderline resectable pancreatic cancer is best treated by multimodality therapy. FOLFIRINOX (5-fluorouracil, oxaliplatin, irinotecan, and leucovorin) tripled the response rate and significantly increased median survival for patients with advanced pancreatic cancer and shows promise for neoadjuvant use. Toxicity concerns prompted a careful analysis of our initial FOLFIRINOX experienc...

Journal: :Tumori 2010
Giampaolo Ugolini Giancarlo Rosati Isacco Montroni Alessio Manaresi Julia Friederike Blume Domenico Schifano Davide Zattoni Mario Taffurelli

AIMS AND BACKGROUND A surgical audit is a systematic critical analysis of surgical performance, with the goal to improve the quality of patient care. Rectal cancer surgery is one of the most delicate procedures in the field of surgical oncology, with significant variations in terms of complications from center to center. Neoadjuvant chemoradiation therapy leads to a significant reduction in loc...

Journal: :Journal of Korean Medical Science 2000
H. R. Kim Y. J. Kim H. J. Kim S. K. Kim J. H. Lee

Telomerase, an enzyme associated with cellular immortality, is expressed by most malignant cells and is inactive in most normal somatic cells, with the exception of proliferative stem cells, germ cells and activated lymphocytes. Measuring telomerase activity clinically may provide useful diagnostic and prognostic information of cancer. The purpose of this study was to investigate the change in ...

Journal: :Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2009
Xavier Benoît D'Journo Jean Philippe Avaro Pierre Michelet Delphine Trousse Anne Marie Tasei Laetitia Dahan Christophe Doddoli Roger Guidicelli Pierre Fuentes Jean Francois Seitz Pascal Thomas

INTRODUCTION To assess prognosis depending on whether lymph node involvement (LNI) is intracapsular or with extracapsular breakthrough in patients with a locally advanced esophageal cancer treated with neoadjuvant chemoradiation and surgery. METHODS Ninety-four consecutive patients with an esophageal cancer staged IIB (n = 17) and III (n = 77) received neoadjuvant chemoradiation followed by t...

Journal: :International Seminars in Surgical Oncology 2006
Myrna Candelaria José Chanona-Vilchis Lucely Cetina Diana Flores-Estrada Carlos López-Graniel Aaron González-Enciso David Cantú Adela Poitevin Lesbia Rivera Jose Hinojosa Jaime de la Garza Alfonso Dueñas-Gonzalez

BACKGROUND Cisplatin-based chemoradiation is the standard of care for locally advanced cervical cancer patients; however, neoadjuvant modalities are currently being tested. Neoadjuvant studies in several tumor types have underscored the prognostic significance of pathological response for survival; however there is a paucity of studies in cervical cancer investigating this issue. METHODS Four...

Journal: :Frontiers in bioscience : a journal and virtual library 1998
W F Regine W J John M Mohiuddin

Only 5% to 15% of patients with pancreatic adenocarcinoma are candidates for a potentially curative resection. Evidence that postoperative adjuvant therapy improves outcome has been limited to a single randomized trial of a well tolerated split-course, 5-Fluorouracil (5-FU) based, chemoradiation regimen. More aggressive regimens have since been developed and are associated with, at best, a mode...

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