OBJECTIVE Activating mutations in the KCNJ11 and ABCC8 genes encoding the Kir6.2 and SUR1 subunits of the pancreatic ATP-sensitive K(+) channel are the most common cause of permanent neonatal diabetes. In contrast to KCNJ11, where only dominant heterozygous mutations have been identified, recessively acting ABCC8 mutations have recently been found in some patients with neonatal diabetes. These ...

BACKGROUND In 2003, the U.S. Preventive Services Task Force concluded that evidence was insufficient to advise for or against routinely screening all pregnant women for gestational diabetes mellitus. PURPOSE To review evidence about the benefits and harms of screening for gestational diabetes. DATA SOURCES Databases (MEDLINE, Database of Abstracts of Reviews of Effects, Health Technology As...

OBJECTIVE To determine the prevalence of monogenic diabetes in an Australian community. DESIGN Longitudinal observational study of a cohort recruited between 2008 and 2011. SETTING Urban population of 157 000 people (Fremantle, Western Australia). PARTICIPANTS 1668 (of 4639 people with diabetes) who consented to participation (36.0% participation). MAIN OUTCOME MEASURES Prevalence of ma...

Neonatal diabetes mellitus (NDM) is a rare kind of diabetes characterized by hyperglycemia and low levels of insulin. Clinically, it is categorized into two main types: transient NDM (TNDM) and permanent NDM (PNDM). These types are diagnosed based on duration of insulin dependence early in the disease. In TNDM, diabetes begins in the first few weeks of life with remission in a few months. Howev...

BACKGROUND Transient Neonatal Diabetes Mellitus is the commonest cause of diabetes presenting in the first week of life. Majority of infants recover by 3 months of age but are predisposed to developing type 2 diabetes later on in life. This condition is usually due to genetic aberrations at the 6q24 gene locus, and can be sporadic or inherited. This disorder has three phases: neonatal diabetes,...

BACKGROUND Macrosomia is associated with considerable neonatal and maternal morbidity. Factors that predict macrosomia are poorly understood. The increased rate of macrosomia in the offspring of pregnant women with diabetes and in congenital hyperinsulinaemia is mediated by increased foetal insulin secretion. We assessed the in utero and neonatal role of two key regulators of pancreatic insulin...

Objetivo: Analisar a relação entre Diabetes Mellitus Gestacional (DMG) e tipo 2 (DM2) com desfechos negativos maternos fetais. Revisão Bibliográfica: O (DM) é uma doença crônica grande relevância para saúde pública, vez que possui alta morbimortalidade. Quando essa ocorre durante gestação, pode ser classificada como diabetes mellitus 1, ou gestacional, sendo os dois últimos, mais prevalentes, p...

conclusions both ua and mca doppler tests were associated with some neonatal outcomes. however, sensitivity of both ua and mca assessments was low in the prediction of adverse neonatal outcomes. by the comparison of these two methods, we found that ua doppler assessment is a better predictor of neonatal outcomes. results based on the findings, poor outcomes were detected in 48 women. nearly 17....

OBJECTIVE Neonatal diabetes mellitus is a rare form of diabetes diagnosed in infancy. Nearly half of patients with permanent neonatal diabetes have mutations in the genes for the ATP-sensitive potassium channel (KCNJ11 and ABCC8) that allow switching from insulin to sulfonylurea therapy. Although treatment conversion has dramatic benefits, the cost-effectiveness of routine genetic testing is un...