the literature about nephrotoxicity of platinum derivatives, which are commonly used in paediatric oncology, such as cisplatin and carboplatin. It shows the incidence, pathomechanisms, risk factors, type and clinical features of the disorders. It presents differences in nephrotoxic effects of particular drugs, and describes possibilities of early detection and monitoring of clinical course and ...

26 Nephrotoxicity is the main complication of gentamicin (GM) treatment. GM induces 27 renal damage by overproduction of reactive oxygen species and inflammation in 28 proximal tubular cells. Phenolic compounds from ginger, called gingerols, have 29 demonstrated to have antioxidant and anti-inflammatory effects. We investigated if the 30 oral treatment with an enriched solution of gingerols (GF...

Ischemia/reperfusion injury (I/R) is commonly related to acute kidney (AKI) and oxidative stress. Antioxidant agents are used treat this condition. Lippia sidoides a brazillian shrub with anti-inflammatory anti-oxidative properties. Thus, the aim of study evaluate effect ethanolic extract (LSEE) on in vivo vitro models AKI induced by I/R. Male Wistar rats were submitted unilateral nephrectomy i...

objective(s):to evaluate the effect of graptophyllum pictum on lipid peroxidation and tissue antioxidant enzymes in liver and kidney of gentamicin induced nephrotoxic rats. materials and methods: animals were grouped into 6: group 1 received gum acacia, group 2 received g. pictum ethanol extract (300 mg/kg), group 3 received gentamicin, groups 4, 5, 6 received gentamicin along with g. pictum at...

Curcumin is the essential ingredient of turmeric and one most potent antioxidants. It also has several biological capabilities, including anti-inflammatory, anticarcinogenic, anticoagulant, antidiabetic, antiviral, antibacterial, antifungal effects. Therefore, curcumin a significant potential for treatment control various diseases. In kidney disorders like chronic disease (CKD) diabetic nephrop...

Mushrooms represent a major and untapped source of potent new pharmaceutical products. The antioxidant, antiinflammatory, antinociceptive, antimutagenic, anticarcinogenic, antitumour, hepatoprotective, nephroprotective and cardioprotective activities of the methanolic extract of Ganoderma lucidum (Fr.) P. Karst. collected from tropical South India were evaluated for the revalidation of its util...

Objective(s):To evaluate the effect of Graptophyllum pictum on lipid peroxidation and tissue antioxidant enzymes in liver and kidney of gentamicin induced nephrotoxic rats. Materials and Methods: Animals were grouped into 6: Group 1 received gum acacia, Group 2 received G. pictum ethanol extract (300 mg/kg), Group 3 received gentamicin, Groups 4, 5, 6 received gentamicin along with G. pictum a...

Pomegranate, Punica granatum L. (Punicaceae), as a medicinal and nutritional ancient fruit, has an outstanding medical history throughout the world. Each of compartments of pomegranate has interesting pharmacological activity. Juice, leaf, flower, and peels of pomegranate possess potent antioxidant properties, while juice, peel and oil are all weakly estrogenic activity. Pomegranate seeds have ...