breast cancer is common and is considered second cause of cancer related mortality in females. regarding importance of breast cancer, more investigation in this field is recommended. for many years investigators believed that neoplasms were not innervated but new findings have proved otherwise. this descriptive study was carried out to compare number of nerve fibers in benign, malignant and nor...

purpose : to evaluate the correlations between visual field (vf) defects with retinal nerve fiber layer (rnfl) thickness in nonarteritic anterior ischemic optic neuropathy (naion) eyes, compare different gdx parameters with the other healthy contralateral eyes, and calculate receiver operating characteristic (roc) curve for the gdx parameters methods : eighteen patients with unilateral naion fr...

Glaucoma is an optic neuropathy that affects the ganglion cell complex in all its components: cell bodies, dendrites, and axons, the dendritic arbor being the first one damaged. This is the reason why the thickness of the ganglion cell and internal plexiform layers can be taken into account as an early predictor of the glaucomatous changes, along with the retinal nerve fiber layer (RNFL) thickn...

INTRODUCTION Peripapillary retinal nerve fiber layer (RNFL) thickness analysis is a subjective method of analysis of glaucomatous damage. As almost 50% of retinal ganglion cells are located in the macula, assessment of macular thickness can be an alternative method for diagnosis of glaucoma. OBJECTIVES To evaluate the changes in macular and retinal nerve fiber layer thickness in controls, gla...

To explore the feasibility of biodegradable fiber-reinforced 3D scaffolds with satisfactory mechanical properties for the repair of long-distance sciatic nerve defect in rabbits and effects of vascularized graft in early stage on the recovery of neurological function, Schwann cells and vascular endothelial cells were cocultured in the fiber-reinforced 3D scaffolds. Experiment group which used p...

We analyzed the relationship between motor nerve conduction velocity (MCV) and morphological changes in regenerating nerve fibers at different times after sciatic nerve transection to identify reliable indices of functional recovery. Thirty rats were divided into five equal groups, one control group and four groups subjected to sciatic nerve transection and immediate suturing, followed by regen...

Purpose To describe spectral-domain optical coherence tomography (OCT) methods for quantifying neuroretinal rim tissue in glaucoma and to compare these methods to the traditional retinal nerve fiber layer thickness diagnostic parameter. Methods Neuroretinal rim parameters derived from three-dimensional (3D) volume scans were compared with the two-dimensional (2D) Spectralis retinal nerve fibe...

PURPOSE To determine the effects of X-linked and autosomal recessive Alport syndrome on retinal basement membranes and how these result in the characteristic perimacular dot-and-fleck retinopathy, lozenge, and macular hole. METHODS The type IV collagen chains present in the normal retina were determined immunohistochemically. Ten patients with Alport syndrome underwent retinal photography and...

OBJECTIVE To evaluate the early effect of sildenafil on the retinal nerve fiber layer (RNFL) thickness. PATIENTS AND METHODS Sixty eyes of 60 patients were enrolled in the study. The patients underwent RNFL analysis by scanning laser polarimetry (Nerve Fiber Analyzer, GDx VCC:5.3.3; Laser Diagnostic Technologies, San Diego, CA, USA) before and after a single 100 mg dose of sildenafil. Sixty e...

OBJECTIVE To evaluate the ability of a tissue-engineered nerve construct composed of a nerve guidance channel and neurally differentiated human adipose tissue-derived stem cells (hASCs) to enhance peripheral nerve regeneration in a rat sciatic nerve model. DESIGN A 13-mm sciatic nerve gap was bridged with silastic conduits in 64 athymic nude rats, and differentiated hASCs were implanted into ...