Although peripheral nerve injury is a common consequence of trauma or surgery, there are insufficient means for repair. In particular, there is a critical need for improved methods to facilitate regeneration of axons across major nerve lesions. Here, we engineered transplantable living nervous tissue constructs to provide a labeled pathway to guide host axonal regeneration. These constructs con...

ABSTRACT The present case report describes a modified technique of coronectomy for mandibular third molar with association Platelet-Rich Fibrin Graft (PRF). panoramic radiograph showed proximity the roots vertical positioned 48 tooth superior wall canal, since erasure cortical canal was observed. Due to risk injury inferior alveolar nerve, chosen. After realized coronectomy, in order promote re...

objective(s):  the aim of this study was to evaluate the final outcome of nerve regeneration across the eggsell membrane (esm) tube conduit in comparison with autograft. materials and methods: thirty adult male rats (250-300 g) were randomized into (1) esm conduit, (2) autograft, and (3) sham surgery groups. the eggs submerged in 5% acetic acid. the decalcifying membranes were cut into four pie...

This video demonstrates a challenging case of giant subclavian and axillary artery aneurysm in patient with Marfan syndrome multiple prior aortic interventions coronary bypass graft presenting nerve compression. was successfully treated via hybrid approach due to complexity. eyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiI2M2RkMDAzODFmMmQ3OTliOTkyZTk2MjA0Y...

Most injuries to the femoral nerve are iatrogenic in origin and occur during resection of large retroperitoneal tumours. When the defect is considerable a nerve graft is mandatory to avoid tension across the suture line. We describe two cases of iatrogenic femoral nerve injury which recovered well after reconstruction with long sural nerve grafts. The probable reasons for success were that we p...

Despite recent progress in vascularized composite allotransplantation (VCA), limitations including complex, high dose immunosuppression regimens, lifelong risk of toxicity from immunosuppressants, acute and most critically chronic graft rejection, and suboptimal nerve regeneration remain particularly challenging obstacles restricting clinical progress. When properly configured, customized, and ...

We investigated whether the use of vascularized peripheral nerve grafts on the optic nerve stump enhances axonal regeneration of retinal ganglion cells compared with isolated nonvascularized grafts. The rat median nerve was microsurgically sutured with its supplying artery and vein to the optic nerve stump. The number of retinal ganglion cells with regenerating axons was evaluated by retrograde...

OBJECTIVE The goal of this study was to determine the various anatomical and surgical relationships between the facial and hypoglossal nerves to define the required length of each for a nerve transfer, either by means of a classical hypoglossal-facial nerve anastomosis or combined with any of its variants developed to reduce tongue morbidities. METHODS Five adult cadaver heads were bilaterall...

We have sought to determine (1) if thalamic neurons upregulate the growth associated protein GAP-43 as a response to injury, or if a peripheral nerve graft is required to induce, enhance or sustain such a response, and (2) if thalamic neurons with different regenerative potentials also display different GAP-43 responses. Levels of GAP-43 protein (detected by LM and EM immunohistochemistry) and ...

Introduction: Reconstructive options for peripheral nerve gaps are currently limited. Autogenous nerve grafts continue to be the gold standard, but are limited by the availability of graft material. All other methods of nerve grafting are either experimental or have limited clinical applicability. We propose developing a tissue engineered peripheral nerve allograft that is non-immunogenic but c...