Nerve growth factor (NGF) affects levels of the alpha subunit of the stimulatory G protein (Gs-alpha) in pheochromocytoma 12 cells in a bidirectional, density-dependent manner. Cells grown at high density responded to NGF treatment with increased levels of Gs-alpha mRNA and protein. Conversely, in cells grown in low-density cultures, levels of this mRNA were lowered by NGF treatment.

background: endometriosis is a common, benign, oestrogen-dependent, chronic gynaecological disorder associated with pelvic pain and infertility. some researchers have identified nerve fibers in endometriotic lesions in women with endometriosis. mesenchymal stem cells (mscs) have attracted interest for their possible use for both cell and gene therapies because of their capacity for self-renewal...

Dental pulp stem cells (DPSCs) secrete neurotrophic factors which may play an important therapeutic role in neural development, maintenance and repair. To test this hypothesis, DPSCs-conditioned medium (DPSCs-CM) was collected from 72 hours serum-free DPSCs cultures. The impact of DPSCs-derived on PC12 survival, growth, migration differentiation investigated. were treated with nerve growth fact...

endometriosis is a common gynaecological disease that can cause severe pelvic pain such as dysmenorrhoea and dyspareunia, however the mechanisms by which pain is generated are not well understood. nerve fibres in endometriotic plaques have been reported by several authors. we have recently demonstrated the presence of unmyelinated sensory nerve fibres (using the pan-neuronal marker pgp9.5) in t...

Recent evidence indicates that cytokines are potent inducers of nerve growth factor (NGF) expression in peripheral tissues and in brain. Cultured rat glomerular mesangial cells respond to interleukin-1 beta (IL-1 beta) and tumour necrosis factor-alpha (TNF-alpha) by increased NGF synthesis. We found that co-stimulation of rat glomerular mesangial cells with platelet-derived growth factor (PGDF-...

Abstract Background Mandibular fracture healing is a complex process involving nerves and growth factors. Nerve factor (NGF) not only facilitates the maintenance of sympathetic neurite but also stimulates other factors that can promote essential osteogenesis angiogenesis for healing. Therefore, it necessary to analyze combined effects NGF, bone morphogenic protein-9 (BMP-9), vascular endothelia...

Recent bioengineering strategies for peripheral nerve regeneration have been focusing on the development of alternative treatments for nerve repair. In this study, we incorporated nerve growth factor (NGF) into aligned core-shell nanofibres by coaxial electrospinning, and reeled the scaffold into aligned fibrous nerve guidance conduits (NGCs) for nerve regeneration study. This aligned PLGA/NGF...

Administration of nervo growth factor (NGF) to the offspring of Spraguc-Dawley rats transplacentally exposed to 50 mg/kg ethylnitrosourea on the 20th day of gestation resulted in a significant reduction of trigemina! and peripheral nerve neurinomas. Forty, 60, and 80 «uof NGF was administered in five s.c. doses, one dose on each of days 12-16, 9094, and 210-214 postnatally. Of the 34 rats in t...