نتایج جستجو برای: neural progenitor cell

تعداد نتایج: 1965368  

Journal: :Neuron 2003
Victoria Graham Jane Khudyakov Pamela Ellis Larysa Pevny

Neural progenitors of the vertebrate CNS are defined by generic cellular characteristics, including their pseudoepithelial morphology and their ability to divide and differentiate. SOXB1 transcription factors, including the three closely related genes Sox1, Sox2, and Sox3, universally mark neural progenitor and stem cells throughout the vertebrate CNS. We show here that constitutive expression ...

Journal: :PLoS ONE 2008
Dean O. Smith Julie L. Rosenheimer Ronald E. Kalil

BACKGROUND Because of the importance of voltage-activated K(+) channels during embryonic development and in cell proliferation, we present here the first description of these channels in E15 rat embryonic neural progenitor cells derived from the subventricular zone (SVZ). Activation, inactivation, and single-channel conductance properties of recorded progenitor cells were compared with those ob...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
Alexander von Holst Swetlana Sirko Andreas Faissner

Neural stem cells have been documented in both the developing and the mature adult CNSs of mammals. This cell population holds a considerable promise for therapeutical applications in a wide array of CNS diseases. Therefore, universally applicable strategies for the purification of this population to further its cell biological characterization are sought. Here, we report that the unique chondr...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
Michael Piper Guy Barry Tracey J Harvey Robert McLeay Aaron G Smith Lachlan Harris Sharon Mason Brett W Stringer Bryan W Day Naomi R Wray Richard M Gronostajski Timothy L Bailey Andrew W Boyd Linda J Richards

Epigenetic mechanisms are essential in regulating neural progenitor cell self-renewal, with the chromatin-modifying protein Enhancer of zeste homolog 2 (EZH2) emerging as a central player in promoting progenitor cell self-renewal during cortical development. Despite this, how Ezh2 is itself regulated remains unclear. Here, we demonstrate that the transcription factor nuclear factor IB (NFIB) pl...

Journal: :iranian journal of veterinary research 2015
t. peirouvi f. yekani m. azarnia m. massumi

hippocampal neural stem/progenitor cells (hipp-ns/pcs) of the adult mammalian brain are important sources of neuronal and gial cell production. in this study, the main goal is to investigate the plasticity of these cells in neuronal/astroglial differentiations. to this end, the differentiation of the hipp-ns/pcs isolated from 3-month-old wistar rats was investigated in response to the embryonic...

Journal: :Molecular and cellular biology 2007
Yuehai Ke Eric E Zhang Kazuki Hagihara Dongmei Wu Yuhong Pang Rüdiger Klein Tom Curran Barbara Ranscht Gen-Sheng Feng

The intracellular signaling controlling neural stem/progenitor cell (NSC) self-renewal and neuronal/glial differentiation is not fully understood. We show here that Shp2, an introcellular tyrosine phosphatase with two SH2 domains, plays a critical role in NSC activities. Conditional deletion of Shp2 in neural progenitor cells mediated by Nestin-Cre resulted in early postnatal lethality, impaire...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Gewei Lian Jie Lu Jianjun Hu Jingping Zhang Sally H Cross Russell J Ferland Volney L Sheen

Cytoskeleton-associated proteins play key roles not only in regulating cell morphology and migration but also in proliferation. Mutations in the cytoskeleton-associated gene filamin A (FlnA) cause the human disorder periventricular heterotopia (PH). PH is a disorder of neural stem cell development that is characterized by disruption of progenitors along the ventricular epithelium and subsequent...

Journal: :Development 2008
Angelo Iulianella Madhulika Sharma Michael Durnin Greg B Vanden Heuvel Paul A Trainor

Neurogenesis requires the coordination of neural progenitor proliferation and differentiation with cell-cycle regulation. However, the mechanisms coordinating these distinct cellular activities are poorly understood. Here we demonstrate for the first time that a Cut-like homeodomain transcription factor family member, Cux2 (Cutl2), regulates cell-cycle progression and development of neural prog...

Journal: :Development 2000
M Handler X Yang J Shen

Mutations in Presenilin-1 (PS1) are a major cause of familial Alzheimer's disease. Our previous studies showed that PS1 is required for murine neural development. Here we report that lack of PS1 leads to premature differentiation of neural progenitor cells, indicating a role for PS1 in a cell fate decision between postmitotic neurons and neural progenitor cells. Neural proliferation and apoptot...

Journal: :Methods in molecular biology 2010
Joseph Peltier David V Schaffer

Genetic manipulation of adult hippocampal neural progenitor cells is a useful technique for exploring gene function through gain of function and loss of function mutations or RNAi. Furthermore, the introduction of new genes can "re-program" progenitor cell behavior to force a desired lineage in signaling environments that are not normally permissive for that cell fate. Additionally, by using a ...

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