Neuroendocrine tumors are rare tumors primarily located in the gastrointestinal tract. Goblet cell carcinoid is a rare subgroup of neuroendocrine tumors located in the appendix. Neurofibromatosis type 1 is an autosomal dominant disorder caused by a mutation in the NF1 gene. Patients with neurofibromatosis type 1 have an increased incidence of typical neuroendocrine tumors, but it is unknown if ...

spinal cord injury (sci) actuate to complex cellular and molecular interactions within the central nervous system in a heave to repair the initial tissue damage. the pathophysiology of acute spinal cord injury (sci) involves primary and secondary mechanisms. neuroinflammation is an important secondary injury process in sci. the local inflammatory microenvironment within the injured spinal cord ...

neuroendocrine cells. Neuroendocrine cells are distributed throughout the gastrointestinal tract, pancreas, lung, thyroid, adrenal gland, and many other organs (1). The gastrointestinal tract has the largest population of neuroendocrine cells, but neuroendocrine malignancies are rare in the colon or rectum (2), accounting for less than 1 percent of all colorectal cancer (3). A PubMed search rev...

Aggressive neuroendocrine lung cancers, including small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), represent an understudied tumor subset that accounts for approximately 40,000 new lung cancer cases per year in the United States. No targeted therapy exists for these tumors. We determined that achaete-scute homolog 1 (ASCL1), a transcription factor required for proper develo...

conclusions liver metastasis of neuroendocrine tumors in iran presents in a very similar manner as that seen in western countries. in about 89% of cases with liver-net, complete imaging, clinical, and pathological studies can help to identify the primary origin of the liver-net, which is very important in the patient’s management. results the most common primary site of metastatic gi-net to the...

Large cell neuroendocrine carcinoma of the ampulla of Vater is extremely rare. A 55 year old woman presented with an ampullary tumour causing pancreaticobiliary obstruction and a panc r ea t i c oduodenec t omy was pe r f o rmed . Microscopically, the tumour was diagnosed as a CD117 positive large cell neuroendocrine carcinoma with glandular differentiation. Four months later the patient develo...

The imaging and pathologic features of three cases of nonlaryngeal neuroendocrine carcinoma of the head and neck are described. Neuroendocrine carcinomas represent malignant epithelial neuroendocrine neoplasms and are classified as three types: typical carcinoid (well differentiated), atypical carcinoid (moderately differentiated), and small cell neuroendocrine (poorly differentiated) carcinoma...

Mucinous carcinoma of the breast is a well-differentiated type of adenocarcinoma accounting for 2-5% of all breast cancers. Pure mucinous carcinoma of the breast has a favorable prognosis, usually seen in post-menopausal women. Neuroendocrine differentiation has been described in both in-situ and infiltrating breast cancers .Mucinous carcinomas of the breast appear to have the greatest associat...

Primary small cell neuroendocrine carcinoma (SCNEC) is a rare high-grade malignant neoplasm with differentiation derived from the urothelium. Herein, we report case which presented symptomatic anaemia secondary to haematuria, complicated acute kidney injury following obstructive uropathy caused by SCNEC, along discussion of clinical presentation, radiological imaging and pathological findings d...

BACKGROUND Small cell neuroendocrine carcinoma is very rarely encountered within the endometrium. CASE STUDY A patient underwent a hysterectomy and salpingo-oophorectomy for a suspicious gynecologic condition. Pathology revealed invasive small cell neuroendocrine carcinoma of the endometrium; the neoplasm exhibited positive immunoreactivity for synaptophysin, pancytokeratin and CD56 but was n...