one of the most important problems in neuroscience researches is the understanding what is the communication between the immune system and central nervous system. proinflammatory factors play an important role in this communication. the dysregulation of proinflammatory factors such as cytokines and chemokines is a central feature in the development of neuroinflammation.one of the important  cyt...

Neuroinflammation is a process characterised by drastic changes in microglial morphology and by marked upregulation of the 18-kDa translocator protein (TSPO) on the mitochondria. The continual increase in incidence of neuroinflammation and neurodegenerative diseases poses a major health issue in many countries, requiring more innovative diagnostic and monitoring tools. TSPO expression may const...

there were many occupational toxins for central nervous system and peripheral nervous system such as toxic and heavy metals. the aim of this study was introduction of occupational toxins with neurological effects and inflammatory effects specially. it is a review article. researcher found the important data about the occupational toxins for nervous systems. author searched in related journals, ...

cognitive impairments describe a state of diminished or impaired mental and/or intellectual function such as alzheimer's disease, huntington's disease and parkinson's disease. as these disorders are more frequent in the elderly and due to the ageing of population, serious attention must be paid to these diseases. exercise has shown to have preventive and therapeutic effects on co...

multiple sclerosis (ms) is the most common autoimmune disease, especially among young’s. neuroinflammation results from inflammation in cns and it may cause different disorders and diseases .it is also known as a detriment in multiple sclerosis. in fact, it causes problems and symptoms in ms. in ms the self-immune cells attack the myelin of neurons, it maybe the nerve in brain or spinal cord. d...

We studied concomitantly the level of neuroinflammation and Aβ load in the APPswePS1dE9 transgenic mouse model of Alzheimer’s disease using PET imaging. The TSPO tracer [F]DPA-714 was used to measure neuroinflammation and [F]AV-45 for Aβ load in mice at 6, 9, 12, 15 and 19 months of age. At 19 months, we also analysed the neuroinflammatory and neuroanatomical status of mice brains. Imaging expe...

Neuroinflammation is known to have a pivotal role in the pathogenesis of Alzheimer's disease (AD), and curcumin has been reported to have therapeutical effects on AD because of its anti-inflammatory effects. Curcumin is not only a potent PPARγ agonist, but also has neuroprotective effects on cerebral ischemic injury. However, whether PPARγ activated by curcumin is responsible for the anti-neuro...

Major depressive disorder (MDD), schizophrenia (SCH), Alzheimer's disease (AD), and Parkinson's disease (PD) are devastating neurological disorders, which increasingly contribute to global morbidity and mortality. Although the pathogenic mechanisms of these conditions are quite diverse, chronic neuroinflammation is one underlying feature shared by all these diseases. Even though the specific ro...

Neuroinflammation is associated with a variety of neurological and pathological diseases, such as Alzheimer's disease (AD), and is reliably detected by the presence of activated microglia. In early AD, the highest degree of activated microglia is observed in brain regions involved in learning and memory. To investigate whether neuroinflammation alters the pattern of rapid de novo gene expressio...