OBJECTIVE To estimate the current incidence and prevalence in the United States of 12 neurologic disorders. METHODS We summarize the strongest evidence available, using data from the United States or from other developed countries when US data were insufficient. RESULTS For some disorders, prevalence is a better descriptor of impact; for others, incidence is preferable. Per 1,000 children, ...

Information about the spectrum of disease caused by hepatitis E virus (HEV) genotype 3 is emerging. During 2004-2009, at 2 hospitals in the United Kingdom and France, among 126 patients with locally acquired acute and chronic HEV genotype 3 infection, neurologic complications developed in 7 (5.5%): inflammatory polyradiculopathy (n = 3), Guillain-Barre syndrome (n = 1), bilateral brachial neuri...

Close to 700 articles can be found in the medical literature relating illness to silicone gel implant mammoplasty. Most of these articles are case series or single case reports describing autoimmune disorders (e.g., rheumatoid arthritis, scleroderma, or lupus erythematosus) in women with silicone gel implants. An estimated one to two million women have these devices implanted. Several recent ar...

global estimate of ShS Burden Call it what you will—passive smoking, environmental tobacco smoke, or secondhand smoke (SHS)—worldwide, exposure to the emissions from smokers’ cigarettes caused the premature death of an estimated 603,000 people in 2004, according to a team of academic and World Health Organization (WHO) researchers. This first global assessment of the burden of SHS was led by Ma...

Wakefulness, NREM sleep, and REM sleep are accompanied by specific changes in breathing control, which arise from the interaction of automatic (metabolic, involuntary) and behavioural (voluntary and involuntary control systems. Considering the complexity in the neuroanatomy and neurophysiology of breathing control, it is not surprising that neurologic disorders are frequently accompanied by sle...

Over 2 years, 104 patients underwent clinical evaluation and laboratory screening for the presence of abnormal anticardiolipin antibodies to determine the profile of laboratory and clinical findings in patients with stroke and other neurologic disorders. Seven with incomplete or ambiguous data were excluded; of the remaining 97 patients, 31 were greater than or equal to 65 years old. Nine patie...

Significant gaps remain in our understanding of the impact of most neurologic disorders, including brain dysfunction and MS. Recent methodology used to assess women with SCIs may be used as a model with which to study these other disorders. The availability of oral agents to treat sexual dysfunction in men should also stimulate research using these agents to treat sexual dysfunction in women.

The effect of autonomic dysfunctions on anemia in various neurological disorders, such as familial amyloidotic polyneuropathy (FAP) Type I, pandysautonomia, and Shy-Drager syndrome was examined. As a control, hemograms of patients with amyotrophic lateral sclerosis (ALS), which is known to be free from autonomic dysfunction, was compared with patients with the above neurological disorders. FAP ...

The kidney and the brain play a major role in maintaining normal homeostasis of the extracellular fluid by neuroendocrine regulation of sodium and water balance. Therefore, disturbances of sodium balance are common in patients with central nervous system (CNS) disorders and clinicians should focus not only on the CNS lesion, but also on the potentially deleterious complications. Hyponatremia is...

Neurologic disease can present as a psychiatric disorder. Understanding underlying neuroanatomic function helps physicians to localize defects and search for treatable neurologic conditions. Neurologic conditions such as Huntington's chorea, Wilson's disease, Gille de la Tourette syndrome, brain tumors, encephalitis and meningitis, neurodegenerative conditions and metabolic or toxic conditions ...