نتایج جستجو برای: neuronal progenitors

تعداد نتایج: 138132  

Journal: :eLife 2016
Tamilla Nechiporuk James McGann Karin Mullendorff Jenny Hsieh Wolfgang Wurst Thomas Floss Gail Mandel

The timely transition from neural progenitor to post-mitotic neuron requires down-regulation and loss of the neuronal transcriptional repressor, REST. Here, we have used mice containing a gene trap in the Rest gene, eliminating transcription from all coding exons, to remove REST prematurely from neural progenitors. We find that catastrophic DNA damage occurs during S-phase of the cell cycle, wi...

Journal: :Mechanisms of Development 2015
Devi Santhosh Zhen Huang

Neural progenitors are central players in the development of the brain neural circuitry. They not only produce the diverse neuronal and glial cell types in the brain, but also guide their migration in this process. Recent evidence indicates that neural progenitors also play a critical role in the development of the brain vascular network. At an early stage, neural progenitors have been found to...

Journal: :Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2011
Hidefumi Fukumitsu

The cerebral cortex is organized into six cell layers, each of which contains neurons with similar morphology, functions, gene-expression profiles, and projection patterns. These layer-specific neuronal phenotypes are sequentially generated from common cortical progenitor cells in the ventricular zone of dorsal telencephalon. Although recent investigations have clarified important roles of intr...

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