objective(s) indigofera tinctoria linn. of fabaceae family is claimed to be useful to control epileptic seizures in the indian system of folkore medicine. this study was designed to evaluate i. tinctoria and to verify the claim. materials and methods seizures were induced in male albino rats with pentylenetetrazole (ptz). the test group animals were administered ethanolic extract of indigofera ...

Uric Acid: Neuroprotective or Neurotoxic? To the Editor: A decades-old scientific dispute pits “as a pro-oxidant, uric acid causes disease”1–3 against “uric acid is an important antioxidant.”2–6 The antioxidant properties of urate are long-known.6 However, arguably, this issue per se originated in our complimentary reports of urate as both a primate evolutionary substitute for ascorbate4 (a put...

Occupational neurotoxic diseases have become increasingly common in Taiwan due to industrialization. Over the past 40 years, Taiwan has transformed from an agricultural society to an industrial society. The most common neurotoxic diseases also changed from organophosphate poisoning to heavy metal intoxication, and then to organic solvent and semiconductor agent poisoning. The nervous system is ...

While zinc is essential for normal brain function and repair, recent work has implicated this trace element in the neuronal damage and death that follow traumatic brain injury, stroke, and seizure. Therefore, the development of new zinc-based therapeutic strategies will need to consider the emerging roles of zinc in the central nervous system.

INTRODUCTION Chemotherapy-induced neuropathies are one of the most common side effects of cancer treatment, surpassing bone marrow suppression and kidney dysfunction. Chemotherapy effects on the nervous system vary between different classes of drugs and depend on specific chemical and physical properties of the drug used. The three most neurotoxic classes of anti-cancer drugs are: platinum-base...

Cadmium (Cd) is a heavy metal that has received considerable concern environmentally and occupationally. Cd has a long biological half-life mainly due to its low rate of excretion from the body. Thus, prolonged exposure to Cd will cause toxic effect due to its accumulation over time in a variety of tissues, including kidneys, liver, central nervous system (CNS), and peripheral neuronal systems....

The importance of biological monitoring, to detect exposure to toxicants and to aid in making decisions about prevention and human health risks, is widely recognized. Thus, in the past few years the study of biomarkers has been the focus of considerable interest in the fields of toxicology, epidemiology, occupational and environmental health (1-5). The development of neurotoxicity is a multiste...