Collapsin response mediator protein 5 (CRMP5) is one of the CRMP members that expresses abundantly in the developing brain. To examine the in vivo function of CRMP5, we generated crmp5-deficient (crmp5(-/-)) mice. Anti-calbindin immunofluorescence studies of crmp5(-/-) mice revealed aberrant dendrite morphology; specifically, a decrease in the size of soma and diameter of primary dendrite of th...

RET proto-oncogene is a receptor tyrosine kinase with three neurotrophic ligands: GDNF, ARTN and NRTN. Activation of central in progression multiple human malignancies; however pathway axis not well defined epithelial cancers. Here, we investigated the tumor enabling capacity cutaneous squamous carcinoma (cSCC) evaluated therapeutic effects blockade. IHC qRT-PCR analysis revealed robust activat...

Erk1/Erk2 MAP kinases are key regulators of cell behaviour and their activation is generally associated with tyrosine kinase signalling. However, TGF-beta stimulation also activates Erk MAP kinases through an undefined mechanism, albeit to a much lower level than receptor tyrosine kinase stimulation. We report that upon TGF-beta stimulation, the activated TGF-beta type I receptor (TbetaRI) recr...

The receptor tyrosine kinase TrkB and its ligands, brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5), are critically important for growth, survival and activity-dependent synaptic strengthening in the central nervous system. These TrkB-mediated actions occur in a highly cell-type specific manner. Here we report that cerebellar Purkinje cells, which are richly endowed with T...

The neurotrophins NGF and NT3 collaborate to support development of sympathetic neurons. Although both promote axonal extension via the TrkA receptor, only NGF activates retrograde transport of TrkA endosomes to support neuronal survival. Here, we report that actin depolymerization is essential for initiation of NGF/TrkA endosome trafficking and that a Rac1-cofilin signaling module associated w...

Ligand signature in the membrane dynamics of single TrkA receptor molecules L. Marchetti , A. Callegari , S. Luin, G. Signore, A. Viegi, F. Beltram and A. Cattaneo 1 NEST, Scuola Normale Superiore and Istituto Nanoscienze – CNR, Piazza San Silvestro 12, I56126 Pisa, Italy. 2 BioSNS Laboratory, Scuola Normale Superiore, c/o Istituto di Neuroscienze del CNR, via Moruzzi 1, I-56100 Pisa, Italy. 3 ...

Functional foods have emerged as a new approach to improve human health in term of nutraceutical to prevent people from illness rather than cure patients though medical treatment. In Asian society, particularly in Thailand, the utilizations of functional ingredients have been integrated in every parts of ordinary life. In this study, the tyrosine kinase activity of epidermal growth factor recep...

Recently, both clinical and animal studies demonstrated neuronal and glial plasticity to be important for the therapeutic action of antidepressants. Antidepressants increase glial cell line-derived neurotrophic factor (GDNF) production through monoamine-independent protein tyrosine kinase (PTK), extracellular signal-regulated kinase (ERK) and cAMP responsive element binding protein (CREB) activ...

background & objectives: anaplastic lymphoma kinase (alk) is a receptor tyrosine kinase involved in the genesis of several human cancers. alk was initially identified because of its involvement in anaplastic large cell lymphoma (alcl). alk is believed to foster tumorigenesis following activation by autocrine and/or paracrine growth loops. studies reveal that the presence of anti-alk antibod...

the rs2476601 (r620w, c1858t) polymorphism in ptpn22 gene has been repeatedly reported to be associated with rheumatoid arthritis (ra). the rs 2476601 is widely suggested for predictive testing and risk assessment for ra. the aim of this study was to test the possible association of this snp with ra in iranian population.a total of 872 samples (405 confirmed ra patients and 467 healthy controls...