Background: Southern IML is the main private provider of laboratory services in NSW, with collection centres located along south coast. Due to its large geographical coverage, samples can travel ∼300km reach for analysis, and this cause delays processing samples. There have been local anecdotal reports ‘artefactual neutropenia’ thought be related delay. This has never clearly described literatu...

Neutropenic colitis is a potentially life-threatening condition with an incidence of approximately 6% and a prevalence of 1-15%. The precipitating event is likely mucosal injury secondary to factors such as chemotherapeutic agents, antibacterial therapy or steroids. The differential diagnosis is wide and early identification relies on a high index of suspicion. This review outlines the pathophy...

Bacillus cereus is increasingly being acknowledged as a serious bacterial pathogen in immunosuppressed hosts. We report a case of fatal B. cereus sepsis in a patient with newly diagnosed acute leukemia following resolving neutropenic enterocolitis. Gastrointestinal complaints are common during induction chemotherapy, yet some antimicrobial coverage suitable for generalized neutropenia is not op...

The classic recommended antifungal agents for the treatment of invasive Candida infections were amphotericin B, a lipid formulation of amphotericin B and fluconazole in both neutropenic or nonneutropenic patients as either primary or alternative therapies. Voriconazole has been recommended when additional coverage for filamentous fungi is needed (e.g. neutropenic patients). More recently and ba...

This study examines the role of neutrophils (PMN) in the pathogenesis of the endothellal lesion induced by a single sublethal dose of endotoxin. It is intended to clarify whether the marginatlon of PMN on endothellum after endotoxin causes intimal injury or is a response to it. Neutropenic rabbits had mean PMN counts of 33/cu mm 72 hr after nitrogen mustard (HN2). They were heparinized and give...

Recent epidemiologic studies have showed that candidemia is an important nosocomial infection in hospitalized patients. The majority of candidemia patients were non-neutropenic rather than neutropenic status. The aim of this study was to determine the clinical outcome of non-neutropenic patients with candidemia and to measure the contributing factors for mortality. A total of 163 non-neutropeni...

OBJECTIVES The purpose of this study was to identify independent factors that can be used to predict whether febrile neutropenic patients who appear healthy at presentation will develop subsequent complications, using variables that are readily available in the emergency department (ED). METHOD The medical records of 192 episodes in which the patients presented to the ED with neutropenic feve...

BACKGROUND AND OBJECTIVES Staphylococcus aureus bacteremia (SAB) continues to be a major problem related to both community and nosocomially acquired infection. Nevertheless few data are presently available in literature about this infection in patients with hematologic malignancies. DESIGN AND METHODS The purpose of this retrospective study was to report further data on the clinical character...

This study examines the role of neutrophils (PMN) in the pathogenesis of the endothellal lesion induced by a single sublethal dose of endotoxin. It is intended to clarify whether the marginatlon of PMN on endothellum after endotoxin causes intimal injury or is a response to it. Neutropenic rabbits had mean PMN counts of 33/cu mm 72 hr after nitrogen mustard (HN2). They were heparinized and give...

This study examines the role of neutrophils (PMN) in the pathogenesis of the endothellal lesion induced by a single sublethal dose of endotoxin. It is intended to clarify whether the marginatlon of PMN on endothellum after endotoxin causes intimal injury or is a response to it. Neutropenic rabbits had mean PMN counts of 33/cu mm 72 hr after nitrogen mustard (HN2). They were heparinized and give...