Objective: Hematological parameters including neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte (PLR), and monocyte–lymphocyte (MLR) have been demonstrated as new predictors of prognosis activity in various diseases. In this study, we aimed to investigate the associations NLR, PLR MLR with disease severity patients anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV). &#...

CASE REPORT We present the case of a 69-year-old woman with unilateral retinal vasculitis. Investigations showed asthma, rhinosinusitis, nasal polyposis, peripheral blood eosinophilia, increased sedimentation rate, proteinuria, and antiphospholipid antibodies. Anti-neutrophil cytoplasmic antibodies (ANCA) were negative. DISCUSSION Although her anti-neutrophil cytoplasmatic antibody (ANCA) sta...

Abstract Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is a rare autoimmune disease with suboptimal treatment options which contribute to morbidity and mortality. The characteristic pathological feature severe inflammation induced by neutrophils causes life threatening damage the small blood vessels of kidney. Neutrophil activity influenced microbial metabolites, inclu...

Circulating IgG autoantibodies that produce cytoplasmic immunofluorescence staining of ethanol-fixed normal neutrophils have recently been found in a large percentage of patients with active Wegener's granulomatosis. Such autoantibodies are rarely found in other diseases and are therefore virtually diagnostic of Wegener's granulomatosis. The nature of the neutrophil antigen defined by these aut...