Infantile hypertrophic pyloric stenosis (IHPS) is a common disease of unknown etiology. The tetrahydrobiopterin (BH4)-deficient hyperphenylalaninemia-1 (hph-1) newborn mouse has a similar phenotype to the human condition. For hph-1 and wild-type control animals, pyloric tissue agonist-induced contractile properties, reactive oxygen species (ROS) generation, cGMP, neuronal nitric oxide synthase ...

T here are many ethical questions concerning research on preterm and newborn infants, why much has to be done on animals. Therefore, research has been, and is continuously done, on newborn lambs, monkeys, pigs, mice, and rats. During the last decades, the use of ‘‘piglets’’ as research animals has become more and more usual. But, what is a piglet, or actually what or who is a piglet? Doing a se...

Rabbits presumably sensitized to components of the streptococcal cell by natural contact with cross-reactive microbial antigens in their environment, display distinctive phases of evolving allergic response to an extract of streptococcal cells. Animals under 4 weeks of age show no gross allergic skin reaction; this is followed successively by age periods in which allergic reactions become most ...

Three out of four carcinomas arising from rims-induced, rabbit papillomas have grown well after transplantation to sucklings. Two were propagated serially, and it seems likely that all could have been maintained indefinitely had litters been available of newborn animals of the sort in which they arose. These successes are the more worthy of note because of the well-nigh uniform failure of simil...

The incidence and localization of tumors in newborn and adult mice of the C57BL/6 strain that received cycasin were compared with similar groups of rats on which results were previously reported. In the present report the newborn mice received single subcutaneous injections of 0.5 mg cycasin/gm body weight within 24 hours after birth. Each adult animal received one dose of 0 .3-1 .0 mg cycasin/...

Some papers are exceedingly short and frequently represent an abstract of work already published in full elsewhere. For the most part the discussions were terribly stinted. To the serious student, there is only a handful of new and worthy information. One such example was an interesting paper by Hofmann on the Micellar Solubilization of Fatty Acids and Monoglycerides in Bile Salt Solutions. The...

Two cutaneous papillomas produced with the Shope virus in adult domestic rabbits were transferred to their leg muscles and thence to those of several successive groups of rabbits of various ages. The growths failed to establish themselves in some newborn animals, but in many formed huge masses, immobilizing the legs with result in early death. Not infrequently they did well for months after the...

In this article, the role of hypothermia and neuroprotection for neonatal encephalopathy will be discussed. The incidence of encephalopathy due to hypoxia ischemia as well as the pathophysiology will be presented. The diagnosis of encephalopathy in full-term neonates will be discussed. The current management of brain injury that occurs with hypoxia ischemia and the role of hypothermia in preven...

A heat-stable protein has recently been isolated from the submaxillary gland of the male mouse which, upon injection, elicits precocious eyelid separation and tooth eruption in the newborn mouse and rat (1). The eyelids of the treated newborn mouse will separate as early as the sixth day after birth, whereas the eyelids of control animals require twelve to thirteen days to separate. The protein...

Cooling is known to prolong survival in newborn animals when used before the onset of asphyxia. It has therefore been advocated as a treatment for birth asphyxia in humans. Since it is not possible to cool a human baby before the onset of birth asphyxia, experiments were designed to test the effect of cooling after asphyxia had already started. Newborn rabbits were asphyxiated in 100% nitrogen ...