Three studies examined the role of need for affect (NFA) and need for cognition (NFC) in intergroup perception. We hypothesized that NFA predicts a preference for stereotypically warm groups over stereotypically cold groups, whereas NFC predicts a preference for stereotypically competent groups over stereotypically incompetent groups. Study 1 supported these hypotheses for attitudes toward ster...

Monthly price and stock data are used to test the influence of Philippine government buffer-stock programs on seasonal and annual variability of producer and consumer rice prices. The period examined is 1974-1990. NFA stock changes are shown to have had some stabilizing influence on seasonal and annual price changes, but the magnitude is small and not statistically significant.

AMPA receptor-mediated excitotoxicity has been implicated in the pathogenesis of stroke, neurotrauma, epilepsy, and many neurodegenerative diseases such as motoneuron disease. We studied the role of Cl- in AMPA receptor-mediated Ca2+-dependent excitotoxicity in cultured rat spinal motoneurons. Using the gramicidin perforated patch-clamp technique, the intracellular Cl- concentration could be ca...

OBJECTIVES/HYPOTHESIS Mucus hypersecretion is a hallmarks of chronic rhinosinusitis. The expression of MUC5AC, a major respiratory mucin gene, is increased in chronic rhinosinusitis. The mechanisms inducing mucus hypersecretion have not been fully evaluated in chronic rhinosinusitis. Human Ca2+ -activated Cl- channel 1 (hCLCA1) is implicated in the regulation of mucus production, airway fluid, ...

Under normal physiological conditions, the open probability of Slo2.1 K(+) channels is low. Elevation of cytosolic [Na(+)] and [Cl(-)] caused by ischemia or rapid electrical pacing of cells increases the open probability of Slo2.1 channels and the resulting outward current can stabilize the resting state of cells. Initial characterization of heterologously expressed human Slo2.1 indicated that ...

Calcium-activated chloride channels (ClCa) are crucial regulators of vascular tone by promoting a depolarizing influence on the resting membrane potential of vascular smooth muscle cells. Niflumic acid (NFA), a potent blocker of ClCa in vascular myocytes, was shown recently to cause inhibition and paradoxical stimulation of sustained calcium-activated chloride currents [ICl(Ca)] in rabbit pulmo...

The objective of the study was to estimate the contractility characteristics and electromechanical coupling of human internal thoracic artery (ITA) by mechanography and double sucrose gap technique to compare the effect of nitroglycerin with other pharmacological agents. The study of mechanical tension (mechanography) of the ITA segments has been performed in 14 patients undergone coronary arte...

Human and pig airway submucosal glands secrete mucus in response to substance P (SubP), but in pig tracheal glands the response to SubP is >10-fold greater than in humans and shares features with cholinergically produced secretion. CFTR-deficient pigs provide a model for human cystic fibrosis (CF), and in newborn CF pigs the response of tracheal glands to SubP is significantly reduced (Joo et a...